Nanoplatforms with synergistic redox cycles and rich defects for activatable image-guided tumor-specific therapy

Hui Zhu; Xinjie Yin; Yue Zhou; Suying Xu; Tony D. James; Leyu Wang

doi:10.1016/j.chempr.2022.06.006

Nanoplatforms with synergistic redox cycles and rich defects for activatable image-guided tumor-specific therapy

Hui Zhu, Xinjie Yin, Yue Zhou, Suying Xu, Tony D. James, Leyu Wang

Research output: Contribution to journal › Article › peer-review

23 Citations (SciVal)

Abstract

Multifunctional nanoplatforms for the early diagnosis and treatment of deep-seated tumors with high specificity are particularly desirable but face many challenges. Herein, nanoplatforms containing copper/manganese chalcogenide nanoflowers (CMC NFs) and ¹⁹F probes have been developed, which exhibit enhanced therapeutic efficiency and activatable ¹⁹F magnetic resonance imaging (MRI) capability within a tumor microenvironment (TME). CMC NFs containing synergistic redox pairs (Cu^ox/Cu^red, Mn^ox/Mn^red) and rich defects acted as integrated cascade enzyme mimics to effectively destroy the redox homeostasis of tumors via generation of reactive oxygen species (ROS) and GSH depletion. In addition, the ¹⁹F MRI signal could be switched on by attenuation of the paramagnetic relaxation enhancement (PRE) effect under TME conditions, affording a TME-activatable ¹⁹F MRI-guided tumor-specific chemodynamic therapeutic. These nanoplatforms could simultaneously boost therapeutic efficacy and regulate signal output, exhibiting significant potential for in vivo drug tracking and deep-seated tumor diagnosis and treatment.

Original language	English
Pages (from-to)	2498-2513
Number of pages	16
Journal	Chem
Volume	8
Issue number	9
Early online date	14 Jul 2022
DOIs	https://doi.org/10.1016/j.chempr.2022.06.006
Publication status	Published - 8 Sept 2022

Bibliographical note

Funding Information:
The authors gratefully acknowledge financial support from the National Natural Science Foundation of China ( 21725501 and 21874007 ) and the Beijing Municipal Natural Science Foundation ( 2212011 ). T.D.J. wishes to thank the Royal Society for a Wolfson Research Merit Award and the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University for support ( 2020ZD01 ).

Data and code availability
The authors declare that the data supporting the findings of this study are available within the article and its Supplemental information. Extra data are available from the corresponding author upon reasonable request.

Keywords

F magnetic resonance imaging
activatable probe
chemodynamic therapy
defects
nanozyme
paramagnetic relaxation enhancement effect
photothermal therapy
SDG3: Good health and well-being
tumor microenvironment

ASJC Scopus subject areas

General Chemistry
Biochemistry
Environmental Chemistry
General Chemical Engineering
Biochemistry, medical
Materials Chemistry

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10.1016/j.chempr.2022.06.006Licence: CC BY

Cite this

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title = "Nanoplatforms with synergistic redox cycles and rich defects for activatable image-guided tumor-specific therapy",

abstract = "Multifunctional nanoplatforms for the early diagnosis and treatment of deep-seated tumors with high specificity are particularly desirable but face many challenges. Herein, nanoplatforms containing copper/manganese chalcogenide nanoflowers (CMC NFs) and 19F probes have been developed, which exhibit enhanced therapeutic efficiency and activatable 19F magnetic resonance imaging (MRI) capability within a tumor microenvironment (TME). CMC NFs containing synergistic redox pairs (Cuox/Cured, Mnox/Mnred) and rich defects acted as integrated cascade enzyme mimics to effectively destroy the redox homeostasis of tumors via generation of reactive oxygen species (ROS) and GSH depletion. In addition, the 19F MRI signal could be switched on by attenuation of the paramagnetic relaxation enhancement (PRE) effect under TME conditions, affording a TME-activatable 19F MRI-guided tumor-specific chemodynamic therapeutic. These nanoplatforms could simultaneously boost therapeutic efficacy and regulate signal output, exhibiting significant potential for in vivo drug tracking and deep-seated tumor diagnosis and treatment.",

keywords = "F magnetic resonance imaging, activatable probe, chemodynamic therapy, defects, nanozyme, paramagnetic relaxation enhancement effect, photothermal therapy, SDG3: Good health and well-being, tumor microenvironment",

author = "Hui Zhu and Xinjie Yin and Yue Zhou and Suying Xu and James, {Tony D.} and Leyu Wang",

note = "Funding Information: The authors gratefully acknowledge financial support from the National Natural Science Foundation of China ( 21725501 and 21874007 ) and the Beijing Municipal Natural Science Foundation ( 2212011 ). T.D.J. wishes to thank the Royal Society for a Wolfson Research Merit Award and the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University for support ( 2020ZD01 ). Data and code availability The authors declare that the data supporting the findings of this study are available within the article and its Supplemental information. Extra data are available from the corresponding author upon reasonable request.",

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AU - Zhu, Hui

AU - Yin, Xinjie

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AU - Xu, Suying

AU - James, Tony D.

AU - Wang, Leyu

N1 - Funding Information: The authors gratefully acknowledge financial support from the National Natural Science Foundation of China ( 21725501 and 21874007 ) and the Beijing Municipal Natural Science Foundation ( 2212011 ). T.D.J. wishes to thank the Royal Society for a Wolfson Research Merit Award and the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University for support ( 2020ZD01 ). Data and code availability The authors declare that the data supporting the findings of this study are available within the article and its Supplemental information. Extra data are available from the corresponding author upon reasonable request.

PY - 2022/9/8

Y1 - 2022/9/8

N2 - Multifunctional nanoplatforms for the early diagnosis and treatment of deep-seated tumors with high specificity are particularly desirable but face many challenges. Herein, nanoplatforms containing copper/manganese chalcogenide nanoflowers (CMC NFs) and 19F probes have been developed, which exhibit enhanced therapeutic efficiency and activatable 19F magnetic resonance imaging (MRI) capability within a tumor microenvironment (TME). CMC NFs containing synergistic redox pairs (Cuox/Cured, Mnox/Mnred) and rich defects acted as integrated cascade enzyme mimics to effectively destroy the redox homeostasis of tumors via generation of reactive oxygen species (ROS) and GSH depletion. In addition, the 19F MRI signal could be switched on by attenuation of the paramagnetic relaxation enhancement (PRE) effect under TME conditions, affording a TME-activatable 19F MRI-guided tumor-specific chemodynamic therapeutic. These nanoplatforms could simultaneously boost therapeutic efficacy and regulate signal output, exhibiting significant potential for in vivo drug tracking and deep-seated tumor diagnosis and treatment.

AB - Multifunctional nanoplatforms for the early diagnosis and treatment of deep-seated tumors with high specificity are particularly desirable but face many challenges. Herein, nanoplatforms containing copper/manganese chalcogenide nanoflowers (CMC NFs) and 19F probes have been developed, which exhibit enhanced therapeutic efficiency and activatable 19F magnetic resonance imaging (MRI) capability within a tumor microenvironment (TME). CMC NFs containing synergistic redox pairs (Cuox/Cured, Mnox/Mnred) and rich defects acted as integrated cascade enzyme mimics to effectively destroy the redox homeostasis of tumors via generation of reactive oxygen species (ROS) and GSH depletion. In addition, the 19F MRI signal could be switched on by attenuation of the paramagnetic relaxation enhancement (PRE) effect under TME conditions, affording a TME-activatable 19F MRI-guided tumor-specific chemodynamic therapeutic. These nanoplatforms could simultaneously boost therapeutic efficacy and regulate signal output, exhibiting significant potential for in vivo drug tracking and deep-seated tumor diagnosis and treatment.

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Nanoplatforms with synergistic redox cycles and rich defects for activatable image-guided tumor-specific therapy

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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Avance III 400 MHz Nuclear Magnetic Resonance (NMR) Spectrometer (9West)

Avance NEO 400 MHz Nuclear Magnetic Resonance (NMR) Spectrometer (1South)

Avance NEO 400 MHz Nuclear Magnetic Resonance (NMR) Spectrometer (new 1South)

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Nanoplatforms with synergistic redox cycles and rich defects for activatable image-guided tumor-specific therapy

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Equipment

Avance III 400 MHz Nuclear Magnetic Resonance (NMR) Spectrometer (9West)

Avance NEO 400 MHz Nuclear Magnetic Resonance (NMR) Spectrometer (1South)

Avance NEO 400 MHz Nuclear Magnetic Resonance (NMR) Spectrometer (new 1South)

Cite this