Nanoplatforms with synergistic redox cycles and rich defects for activatable image-guided tumor-specific therapy

Hui Zhu, Xinjie Yin, Yue Zhou, Suying Xu, Tony D. James, Leyu Wang

Research output: Contribution to journalArticlepeer-review

Abstract

Multifunctional nanoplatforms for the early diagnosis and treatment of deep-seated tumors with high specificity are particularly desirable but face many challenges. Herein, nanoplatforms containing copper/manganese chalcogenide nanoflowers (CMC NFs) and 19F probes have been developed, which exhibit enhanced therapeutic efficiency and activatable 19F magnetic resonance imaging (MRI) capability within a tumor microenvironment (TME). CMC NFs containing synergistic redox pairs (Cuox/Cured, Mnox/Mnred) and rich defects acted as integrated cascade enzyme mimics to effectively destroy the redox homeostasis of tumors via generation of reactive oxygen species (ROS) and GSH depletion. In addition, the 19F MRI signal could be switched on by attenuation of the paramagnetic relaxation enhancement (PRE) effect under TME conditions, affording a TME-activatable 19F MRI-guided tumor-specific chemodynamic therapeutic. These nanoplatforms could simultaneously boost therapeutic efficacy and regulate signal output, exhibiting significant potential for in vivo drug tracking and deep-seated tumor diagnosis and treatment.

Original languageEnglish
Pages (from-to)2498-2513
Number of pages16
JournalChem
Volume8
Issue number9
Early online date14 Jul 2022
DOIs
Publication statusPublished - 8 Sep 2022

Keywords

  • F magnetic resonance imaging
  • activatable probe
  • chemodynamic therapy
  • defects
  • nanozyme
  • paramagnetic relaxation enhancement effect
  • photothermal therapy
  • SDG3: Good health and well-being
  • tumor microenvironment

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry
  • Environmental Chemistry
  • Chemical Engineering(all)
  • Biochemistry, medical
  • Materials Chemistry

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