Nanococktail Based on Supramolecular Glyco-Assembly for Eradicating Tumors In Vivo

Weiwei Feng; Shangqian Zhang; Yichen Wan; Zelong Chen; Yun Qu; Jiahui Li; Tony D. James; Zhichao Pei; Yuxin Pei

doi:10.1021/acsami.2c03463

Nanococktail Based on Supramolecular Glyco-Assembly for Eradicating Tumors In Vivo

Weiwei Feng, Shangqian Zhang, Yichen Wan, Zelong Chen, Yun Qu, Jiahui Li, Tony D. James, Zhichao Pei, Yuxin Pei

Northwest AandF University

Research output: Contribution to journal › Article › peer-review

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Abstract

The development of robust phototherapeutic strategies for eradicating tumors remains a significant challenge in the transfer of cancer phototherapy to clinical practice. Here, a phototherapeutic nanococktail atovaquone/17-dimethylaminoethylamino-17-demethoxygeldanamycin/glyco-BODIPY (ADB) was developed to enhance photodynamic therapy (PDT) and photothermal therapy (PTT) via alleviation of hypoxia and thermal resistance that was constructed using supramolecular self-assembly of glyco-BODIPY (BODIPY-SS-LAC, BSL-1), hypoxia reliever atovaquone (ATO), and heat shock protein inhibitor 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG). Benefiting from a glyco-targeting and glutathione (GSH) responsive units BSL-1, ADB can be rapidly taken up by hepatoma cells, furthermore the loaded ATO and 17-DMAG can be released in original form into the cytoplasm. Using in vitro and in vivo results, it was confirmed that ADB enhanced the synergetic PDT and PTT upon irradiation using 685 nm near-infrared light (NIR) under a hypoxic tumor microenvironment where ATO can reduce O2 consumption and 17-DMAG can down-regulate HSP90. Moreover, ADB exhibited good biosafety, and tumor eradication in vivo. Hence, this as-developed phototherapeutic nanococktail overcomes the substantial obstacles encountered by phototherapy in tumor treatment and offers a promising approach for the eradication of tumors.

Original language	English
Pages (from-to)	20749-20761
Number of pages	13
Journal	ACS Applied Materials and Interfaces
Volume	14
Issue number	18
Early online date	28 Apr 2022
DOIs	https://doi.org/10.1021/acsami.2c03463
Publication status	Published - 11 May 2022

Bibliographical note

Funding Information:
This work was supported by the National Natural Science Foundation of China (21772157 and 21877088) and the Project of Science and Technology of Social Development in Shaanxi Province (2021SF-120). T.D.J. wishes to thank the Royal Society for a Wolfson Research Merit Award and the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University for support (2020ZD01).

Publisher Copyright:
© 2022 American Chemical Society.

Keywords

cancer therapy
hypoxia
phototherapeutic nanococktail
supramolecular glyco-assembly
thermal resistance

ASJC Scopus subject areas

General Materials Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/acsami.2c03463

Manuscript
This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Appl. Mater. Interfaces, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acsami.2c03463
Accepted author manuscript, 1.91 MB

Cite this

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title = "Nanococktail Based on Supramolecular Glyco-Assembly for Eradicating Tumors In Vivo",

abstract = "The development of robust phototherapeutic strategies for eradicating tumors remains a significant challenge in the transfer of cancer phototherapy to clinical practice. Here, a phototherapeutic nanococktail atovaquone/17-dimethylaminoethylamino-17-demethoxygeldanamycin/glyco-BODIPY (ADB) was developed to enhance photodynamic therapy (PDT) and photothermal therapy (PTT) via alleviation of hypoxia and thermal resistance that was constructed using supramolecular self-assembly of glyco-BODIPY (BODIPY-SS-LAC, BSL-1), hypoxia reliever atovaquone (ATO), and heat shock protein inhibitor 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG). Benefiting from a glyco-targeting and glutathione (GSH) responsive units BSL-1, ADB can be rapidly taken up by hepatoma cells, furthermore the loaded ATO and 17-DMAG can be released in original form into the cytoplasm. Using in vitro and in vivo results, it was confirmed that ADB enhanced the synergetic PDT and PTT upon irradiation using 685 nm near-infrared light (NIR) under a hypoxic tumor microenvironment where ATO can reduce O2 consumption and 17-DMAG can down-regulate HSP90. Moreover, ADB exhibited good biosafety, and tumor eradication in vivo. Hence, this as-developed phototherapeutic nanococktail overcomes the substantial obstacles encountered by phototherapy in tumor treatment and offers a promising approach for the eradication of tumors. ",

keywords = "cancer therapy, hypoxia, phototherapeutic nanococktail, supramolecular glyco-assembly, thermal resistance",

author = "Weiwei Feng and Shangqian Zhang and Yichen Wan and Zelong Chen and Yun Qu and Jiahui Li and James, {Tony D.} and Zhichao Pei and Yuxin Pei",

note = "Funding Information: This work was supported by the National Natural Science Foundation of China (21772157 and 21877088) and the Project of Science and Technology of Social Development in Shaanxi Province (2021SF-120). T.D.J. wishes to thank the Royal Society for a Wolfson Research Merit Award and the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University for support (2020ZD01). Publisher Copyright: {\textcopyright} 2022 American Chemical Society.",

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AU - Feng, Weiwei

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AU - Qu, Yun

AU - Li, Jiahui

AU - James, Tony D.

AU - Pei, Zhichao

AU - Pei, Yuxin

N1 - Funding Information: This work was supported by the National Natural Science Foundation of China (21772157 and 21877088) and the Project of Science and Technology of Social Development in Shaanxi Province (2021SF-120). T.D.J. wishes to thank the Royal Society for a Wolfson Research Merit Award and the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University for support (2020ZD01). Publisher Copyright: © 2022 American Chemical Society.

PY - 2022/5/11

Y1 - 2022/5/11

N2 - The development of robust phototherapeutic strategies for eradicating tumors remains a significant challenge in the transfer of cancer phototherapy to clinical practice. Here, a phototherapeutic nanococktail atovaquone/17-dimethylaminoethylamino-17-demethoxygeldanamycin/glyco-BODIPY (ADB) was developed to enhance photodynamic therapy (PDT) and photothermal therapy (PTT) via alleviation of hypoxia and thermal resistance that was constructed using supramolecular self-assembly of glyco-BODIPY (BODIPY-SS-LAC, BSL-1), hypoxia reliever atovaquone (ATO), and heat shock protein inhibitor 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG). Benefiting from a glyco-targeting and glutathione (GSH) responsive units BSL-1, ADB can be rapidly taken up by hepatoma cells, furthermore the loaded ATO and 17-DMAG can be released in original form into the cytoplasm. Using in vitro and in vivo results, it was confirmed that ADB enhanced the synergetic PDT and PTT upon irradiation using 685 nm near-infrared light (NIR) under a hypoxic tumor microenvironment where ATO can reduce O2 consumption and 17-DMAG can down-regulate HSP90. Moreover, ADB exhibited good biosafety, and tumor eradication in vivo. Hence, this as-developed phototherapeutic nanococktail overcomes the substantial obstacles encountered by phototherapy in tumor treatment and offers a promising approach for the eradication of tumors.

AB - The development of robust phototherapeutic strategies for eradicating tumors remains a significant challenge in the transfer of cancer phototherapy to clinical practice. Here, a phototherapeutic nanococktail atovaquone/17-dimethylaminoethylamino-17-demethoxygeldanamycin/glyco-BODIPY (ADB) was developed to enhance photodynamic therapy (PDT) and photothermal therapy (PTT) via alleviation of hypoxia and thermal resistance that was constructed using supramolecular self-assembly of glyco-BODIPY (BODIPY-SS-LAC, BSL-1), hypoxia reliever atovaquone (ATO), and heat shock protein inhibitor 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG). Benefiting from a glyco-targeting and glutathione (GSH) responsive units BSL-1, ADB can be rapidly taken up by hepatoma cells, furthermore the loaded ATO and 17-DMAG can be released in original form into the cytoplasm. Using in vitro and in vivo results, it was confirmed that ADB enhanced the synergetic PDT and PTT upon irradiation using 685 nm near-infrared light (NIR) under a hypoxic tumor microenvironment where ATO can reduce O2 consumption and 17-DMAG can down-regulate HSP90. Moreover, ADB exhibited good biosafety, and tumor eradication in vivo. Hence, this as-developed phototherapeutic nanococktail overcomes the substantial obstacles encountered by phototherapy in tumor treatment and offers a promising approach for the eradication of tumors.

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JO - ACS Applied Materials and Interfaces

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ER -

Nanococktail Based on Supramolecular Glyco-Assembly for Eradicating Tumors In Vivo

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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