Abstract
We report an enzyme-activated fluorescence based probe (NHPO) for the selective detection of N-acetyl-β-d-glucosaminidase (NAG) activity in a drug-induced kidney injury mice model and NAG level in crude human urine. We used NHPO to explore the biological functions of NAG and provide a reference for the prognosis and prediction of proximal renal tubular dysfunction associated with various kidney diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 1955-1958 |
| Number of pages | 4 |
| Journal | Chemical communications (Cambridge, England) |
| Volume | 55 |
| Issue number | 13 |
| Early online date | 14 Jan 2019 |
| DOIs | |
| Publication status | Published - 14 Feb 2019 |
Keywords
- Acetylglucosaminidase/analysis
- Animals
- Disease Models, Animal
- Fluorescent Dyes/chemistry
- Kidney/diagnostic imaging
- Kidney Diseases/diagnostic imaging
- Mice
- Mice, Inbred C57BL
- Optical Imaging
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Metals and Alloys
- Materials Chemistry
- Surfaces, Coatings and Films
- General Chemistry
- Catalysis
