NAG-targeting fluorescence based probe for precision diagnosis of kidney injury

Fei Yan, Xiangge Tian, Zhilin Luan, Lei Feng, Xiaochi Ma, Tony D. James

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We report an enzyme-activated fluorescence based probe (NHPO) for the selective detection of N-acetyl-β-d-glucosaminidase (NAG) activity in a drug-induced kidney injury mice model and NAG level in crude human urine. We used NHPO to explore the biological functions of NAG and provide a reference for the prognosis and prediction of proximal renal tubular dysfunction associated with various kidney diseases.

Original languageEnglish
Pages (from-to)1955-1958
Number of pages4
JournalChemical communications (Cambridge, England)
Volume55
Issue number13
Early online date14 Jan 2019
DOIs
Publication statusPublished - 14 Feb 2019

Keywords

  • Acetylglucosaminidase/analysis
  • Animals
  • Disease Models, Animal
  • Fluorescent Dyes/chemistry
  • Kidney/diagnostic imaging
  • Kidney Diseases/diagnostic imaging
  • Mice
  • Mice, Inbred C57BL
  • Optical Imaging

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Chemistry(all)
  • Catalysis

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