Myositis-specific autoantibodies: an important tool to support diagnosis of myositis

Z. Betteridge, N. McHugh

Research output: Contribution to journalArticle

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Abstract

The idiopathic inflammatory myopathies are characterised by muscle weakness, skin disease and internal organ involvement. Autoimmunity is known to have a role in myositis pathogenesis, and myositis specific autoantibodies, targeting important intracellular proteins, are regarded as key biomarkers aiding in the diagnosis of patients. In recent years a number of novel myositis autoantibodies including; anti-TIF1, anti-NXP2, anti-MDA5, anti-SAE, anti-HMGCR and anti-cN1A have been identified in both adult and juvenile patients. These autoantibodies correlate with distinct clinical manifestations, and importantly are found in the inclusion body, statin-induced, clinically amyopathic and juvenile groups of myositis patients that were previously believed to be mainly autoantibody negative.
LanguageEnglish
Pages8-23
JournalJournal of Internal Medicine
Volume280
Issue number1
Early online date25 Nov 2015
DOIs
StatusPublished - Jul 2016

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Myositis
Autoantibodies
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Inclusion Bodies
Muscle Weakness
Autoimmunity
Skin Diseases
Biomarkers
Proteins

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Myositis-specific autoantibodies : an important tool to support diagnosis of myositis. / Betteridge, Z.; McHugh, N.

In: Journal of Internal Medicine, Vol. 280, No. 1, 07.2016, p. 8-23.

Research output: Contribution to journalArticle

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