Projects per year
Abstract
The idiopathic inflammatory myopathies are characterised by muscle weakness, skin disease and internal organ involvement. Autoimmunity is known to have a role in myositis pathogenesis, and myositis specific autoantibodies, targeting important intracellular proteins, are regarded as key biomarkers aiding in the diagnosis of patients. In recent years a number of novel myositis autoantibodies including; anti-TIF1, anti-NXP2, anti-MDA5, anti-SAE, anti-HMGCR and anti-cN1A have been identified in both adult and juvenile patients. These autoantibodies correlate with distinct clinical manifestations, and importantly are found in the inclusion body, statin-induced, clinically amyopathic and juvenile groups of myositis patients that were previously believed to be mainly autoantibody negative.
Original language | English |
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Pages (from-to) | 8-23 |
Journal | Journal of Internal Medicine |
Volume | 280 |
Issue number | 1 |
Early online date | 25 Nov 2015 |
DOIs | |
Publication status | Published - Jul 2016 |
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- 1 Finished
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MRC CiC - Glucose Pathfinder
Ilie, A. (PI), Guy, R. (CoI) & Tyrrell, R. (CoI)
1/10/15 → 30/06/16
Project: Research council