Myositis-specific autoantibodies: an important tool to support diagnosis of myositis

Z. Betteridge, N. McHugh

Research output: Contribution to journalArticle

142 Citations (Scopus)

Abstract

The idiopathic inflammatory myopathies are characterised by muscle weakness, skin disease and internal organ involvement. Autoimmunity is known to have a role in myositis pathogenesis, and myositis specific autoantibodies, targeting important intracellular proteins, are regarded as key biomarkers aiding in the diagnosis of patients. In recent years a number of novel myositis autoantibodies including; anti-TIF1, anti-NXP2, anti-MDA5, anti-SAE, anti-HMGCR and anti-cN1A have been identified in both adult and juvenile patients. These autoantibodies correlate with distinct clinical manifestations, and importantly are found in the inclusion body, statin-induced, clinically amyopathic and juvenile groups of myositis patients that were previously believed to be mainly autoantibody negative.
Original languageEnglish
Pages (from-to)8-23
JournalJournal of Internal Medicine
Volume280
Issue number1
Early online date25 Nov 2015
DOIs
Publication statusPublished - Jul 2016

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