Myositis specific and associated autoantibodies in the diagnosis and management of juvenile and adult idiopathic inflammatory myopathies

Sarah L Tansley, Neil J McHugh

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Abstract

The idiopathic inflammatory myopathies are a heterogeneous group of disorders affecting both adults and children. Clinical features can include muscle weakness, skin disease and internal organ involvement. A large number of autoantibodies, directed against cytoplasmic or nuclear components, can now be identified in these patients and specific clinic-serological syndromes have been described. Laboratory testing to identify many of these autoantibodies is becoming easier, and here we discuss the clinical utility of autoantibodies in myositis both in terms of facilitating diagnosis, predicting disease course and informing management decisions.

LanguageEnglish
Pages464
JournalCurrent Rheumatology Reports
Volume16
Issue number12
DOIs
StatusPublished - Dec 2014

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Myositis
Autoantibodies
Muscle Weakness
Skin Diseases

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