Mutations affecting xanthophore pigmentation in the zebrafish, Danio rerio

J Odenthal, K Rossnagel, P Haffter, R N Kelsh, E Vogelsang, M Brand, F J M vanEeden, Makoto Furutani-Seiki, M Granato, M Hammerschmidt, C P Heisenberg, Y J Jiang, D A Kane, M C Mullins, C NussleinVolhard

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Abstract

In a large-scale screen for mutants with defects in embryonic development we identified 17 genes (65 mutants) specifically required for the development of xanthophores, We provide evidence that these genes are required for three different aspects of xanthophore development, (1) Pigment cell formation and migration (pfeffer and salt); (2) pigment synthesis (edison, yobo, yocca and brie) and (3) pigment translocation (esrom, tilsit and tofu). The number of xanthophore cells that appear in the body is reduced in embryos with mutations in the two genes, salt and pfeffer. In heterozygous and homozygous salt and pfeffer adults, the melanophore stripes are interrupted, indicating that xanthophore cells have an important function in adult melanophore pattern formation, Most other genes affect only larval pigmentation, In embryos mutant for edison, yobo, yocca and brie, differences in pteridine synthesis can be observed under UV light and by thin-layer chromatography. Homozygous mutant females of yobo show a recessive maternal effect, Embryonic development is slowed down and embryos display head and tail truncations, Xanthophores in larvae mutant in the three genes esrom, tilsit and tofu appear less spread out, In addition, these mutants display a defect in retinotectal axon pathfinding, These mutations may affect xanthophore pigment distribution within the cells or xanthophore cell shape, Mutations in seven genes affecting xanthophore pigmentation remain unclassified.
LanguageEnglish
Pages391-398
Number of pages8
JournalDevelopment
Volume123
StatusPublished - 1996

Fingerprint

Pigmentation
Zebrafish
Mutation
Melanophores
Genes
Soy Foods
Embryonic Structures
Salts
Embryonic Development
Pteridines
Cell Shape
Ultraviolet Rays
Thin Layer Chromatography
Cell Movement
Larva
Tail
Cell Count

Keywords

  • maternal effect
  • pteridines
  • pigment cells
  • xanthophores
  • translocation
  • pigment pattern
  • pigment
  • chromatophores

Cite this

Odenthal, J., Rossnagel, K., Haffter, P., Kelsh, R. N., Vogelsang, E., Brand, M., ... NussleinVolhard, C. (1996). Mutations affecting xanthophore pigmentation in the zebrafish, Danio rerio.

Mutations affecting xanthophore pigmentation in the zebrafish, Danio rerio. / Odenthal, J; Rossnagel, K; Haffter, P; Kelsh, R N; Vogelsang, E; Brand, M; vanEeden, F J M; Furutani-Seiki, Makoto; Granato, M; Hammerschmidt, M; Heisenberg, C P; Jiang, Y J; Kane, D A; Mullins, M C; NussleinVolhard, C.

In: Development, Vol. 123, 1996, p. 391-398.

Research output: Contribution to journalArticle

Odenthal, J, Rossnagel, K, Haffter, P, Kelsh, RN, Vogelsang, E, Brand, M, vanEeden, FJM, Furutani-Seiki, M, Granato, M, Hammerschmidt, M, Heisenberg, CP, Jiang, YJ, Kane, DA, Mullins, MC & NussleinVolhard, C 1996, 'Mutations affecting xanthophore pigmentation in the zebrafish, Danio rerio' Development, vol. 123, pp. 391-398.
Odenthal J, Rossnagel K, Haffter P, Kelsh RN, Vogelsang E, Brand M et al. Mutations affecting xanthophore pigmentation in the zebrafish, Danio rerio. Development. 1996;123:391-398.
Odenthal, J ; Rossnagel, K ; Haffter, P ; Kelsh, R N ; Vogelsang, E ; Brand, M ; vanEeden, F J M ; Furutani-Seiki, Makoto ; Granato, M ; Hammerschmidt, M ; Heisenberg, C P ; Jiang, Y J ; Kane, D A ; Mullins, M C ; NussleinVolhard, C. / Mutations affecting xanthophore pigmentation in the zebrafish, Danio rerio. In: Development. 1996 ; Vol. 123. pp. 391-398
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AU - Rossnagel,K

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AU - Kelsh,R N

AU - Vogelsang,E

AU - Brand,M

AU - vanEeden,F J M

AU - Furutani-Seiki,Makoto

AU - Granato,M

AU - Hammerschmidt,M

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N2 - In a large-scale screen for mutants with defects in embryonic development we identified 17 genes (65 mutants) specifically required for the development of xanthophores, We provide evidence that these genes are required for three different aspects of xanthophore development, (1) Pigment cell formation and migration (pfeffer and salt); (2) pigment synthesis (edison, yobo, yocca and brie) and (3) pigment translocation (esrom, tilsit and tofu). The number of xanthophore cells that appear in the body is reduced in embryos with mutations in the two genes, salt and pfeffer. In heterozygous and homozygous salt and pfeffer adults, the melanophore stripes are interrupted, indicating that xanthophore cells have an important function in adult melanophore pattern formation, Most other genes affect only larval pigmentation, In embryos mutant for edison, yobo, yocca and brie, differences in pteridine synthesis can be observed under UV light and by thin-layer chromatography. Homozygous mutant females of yobo show a recessive maternal effect, Embryonic development is slowed down and embryos display head and tail truncations, Xanthophores in larvae mutant in the three genes esrom, tilsit and tofu appear less spread out, In addition, these mutants display a defect in retinotectal axon pathfinding, These mutations may affect xanthophore pigment distribution within the cells or xanthophore cell shape, Mutations in seven genes affecting xanthophore pigmentation remain unclassified.

AB - In a large-scale screen for mutants with defects in embryonic development we identified 17 genes (65 mutants) specifically required for the development of xanthophores, We provide evidence that these genes are required for three different aspects of xanthophore development, (1) Pigment cell formation and migration (pfeffer and salt); (2) pigment synthesis (edison, yobo, yocca and brie) and (3) pigment translocation (esrom, tilsit and tofu). The number of xanthophore cells that appear in the body is reduced in embryos with mutations in the two genes, salt and pfeffer. In heterozygous and homozygous salt and pfeffer adults, the melanophore stripes are interrupted, indicating that xanthophore cells have an important function in adult melanophore pattern formation, Most other genes affect only larval pigmentation, In embryos mutant for edison, yobo, yocca and brie, differences in pteridine synthesis can be observed under UV light and by thin-layer chromatography. Homozygous mutant females of yobo show a recessive maternal effect, Embryonic development is slowed down and embryos display head and tail truncations, Xanthophores in larvae mutant in the three genes esrom, tilsit and tofu appear less spread out, In addition, these mutants display a defect in retinotectal axon pathfinding, These mutations may affect xanthophore pigment distribution within the cells or xanthophore cell shape, Mutations in seven genes affecting xanthophore pigmentation remain unclassified.

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