Mutations affecting morphogenesis during gastrulation and tail formation in the zebrafish, Danio rerio

M Hammerschmidt, F Pelegri, M C Mullins, D A Kane, M Brand, F J M vanEeden, Makoto Furutani-Seiki, M Granato, P Haffter, C P Heisenberg, Y J Jiang, R N Kelsh, J Odenthal, R M Warga, C NussleinVolhard

Research output: Contribution to journalArticle

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Abstract

We have identified several genes that are required for various morphogenetic processes during gastrulation and tail formation, Two genes are required in the anterior region of the body axis: one eyed pinhead (oep) and dir ty nose (dns). oep mutant embryos are defective in prechordal plate formation and the specification of anterior and ventral structures of the central nervous system, In dns mutants, cells of the prechordal plate, such as the prospective hatching gland cells, fail to specify. Two genes are required for convergence and extension movements. In mutant trilobite embryos, extension movements on the dorsal side of the embryo are affected, whereas in the formerly described spadetail mutants, for which two new alleles have been isolated, convergent movements of ventrolateral cells to the dorsal side are blocked. Two genes are required for the development of the posterior end of the body axis, In pipetail mutants, the tailbud fails to move ventrally on the yolk sac after germ ring closure, and the tip of the tail fails to detach from the yolk tube. Mutants in kugelig (kgg) do not form the yolk tube at the posterior side of the yolk sac.
Original languageEnglish
Pages (from-to)143-151
Number of pages9
JournalDevelopment
Volume123
Publication statusPublished - 1996

Fingerprint

Gastrulation
Zebrafish
Morphogenesis
Tail
Yolk Sac
Mutation
Embryonic Structures
Nose
Genes
Body Regions
Cell Movement
Central Nervous System
Alleles

Keywords

  • spadetail
  • trilobite
  • tail formation
  • gastrulation
  • pipetail
  • cyclopia
  • zebrafish
  • kugelig
  • one-eyed-pinhead
  • axis extension

Cite this

Hammerschmidt, M., Pelegri, F., Mullins, M. C., Kane, D. A., Brand, M., vanEeden, F. J. M., ... NussleinVolhard, C. (1996). Mutations affecting morphogenesis during gastrulation and tail formation in the zebrafish, Danio rerio. Development, 123, 143-151.

Mutations affecting morphogenesis during gastrulation and tail formation in the zebrafish, Danio rerio. / Hammerschmidt, M; Pelegri, F; Mullins, M C; Kane, D A; Brand, M; vanEeden, F J M; Furutani-Seiki, Makoto; Granato, M; Haffter, P; Heisenberg, C P; Jiang, Y J; Kelsh, R N; Odenthal, J; Warga, R M; NussleinVolhard, C.

In: Development, Vol. 123, 1996, p. 143-151.

Research output: Contribution to journalArticle

Hammerschmidt, M, Pelegri, F, Mullins, MC, Kane, DA, Brand, M, vanEeden, FJM, Furutani-Seiki, M, Granato, M, Haffter, P, Heisenberg, CP, Jiang, YJ, Kelsh, RN, Odenthal, J, Warga, RM & NussleinVolhard, C 1996, 'Mutations affecting morphogenesis during gastrulation and tail formation in the zebrafish, Danio rerio', Development, vol. 123, pp. 143-151.
Hammerschmidt M, Pelegri F, Mullins MC, Kane DA, Brand M, vanEeden FJM et al. Mutations affecting morphogenesis during gastrulation and tail formation in the zebrafish, Danio rerio. Development. 1996;123:143-151.
Hammerschmidt, M ; Pelegri, F ; Mullins, M C ; Kane, D A ; Brand, M ; vanEeden, F J M ; Furutani-Seiki, Makoto ; Granato, M ; Haffter, P ; Heisenberg, C P ; Jiang, Y J ; Kelsh, R N ; Odenthal, J ; Warga, R M ; NussleinVolhard, C. / Mutations affecting morphogenesis during gastrulation and tail formation in the zebrafish, Danio rerio. In: Development. 1996 ; Vol. 123. pp. 143-151.
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abstract = "We have identified several genes that are required for various morphogenetic processes during gastrulation and tail formation, Two genes are required in the anterior region of the body axis: one eyed pinhead (oep) and dir ty nose (dns). oep mutant embryos are defective in prechordal plate formation and the specification of anterior and ventral structures of the central nervous system, In dns mutants, cells of the prechordal plate, such as the prospective hatching gland cells, fail to specify. Two genes are required for convergence and extension movements. In mutant trilobite embryos, extension movements on the dorsal side of the embryo are affected, whereas in the formerly described spadetail mutants, for which two new alleles have been isolated, convergent movements of ventrolateral cells to the dorsal side are blocked. Two genes are required for the development of the posterior end of the body axis, In pipetail mutants, the tailbud fails to move ventrally on the yolk sac after germ ring closure, and the tip of the tail fails to detach from the yolk tube. Mutants in kugelig (kgg) do not form the yolk tube at the posterior side of the yolk sac.",
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AU - Hammerschmidt, M

AU - Pelegri, F

AU - Mullins, M C

AU - Kane, D A

AU - Brand, M

AU - vanEeden, F J M

AU - Furutani-Seiki, Makoto

AU - Granato, M

AU - Haffter, P

AU - Heisenberg, C P

AU - Jiang, Y J

AU - Kelsh, R N

AU - Odenthal, J

AU - Warga, R M

AU - NussleinVolhard, C

PY - 1996

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N2 - We have identified several genes that are required for various morphogenetic processes during gastrulation and tail formation, Two genes are required in the anterior region of the body axis: one eyed pinhead (oep) and dir ty nose (dns). oep mutant embryos are defective in prechordal plate formation and the specification of anterior and ventral structures of the central nervous system, In dns mutants, cells of the prechordal plate, such as the prospective hatching gland cells, fail to specify. Two genes are required for convergence and extension movements. In mutant trilobite embryos, extension movements on the dorsal side of the embryo are affected, whereas in the formerly described spadetail mutants, for which two new alleles have been isolated, convergent movements of ventrolateral cells to the dorsal side are blocked. Two genes are required for the development of the posterior end of the body axis, In pipetail mutants, the tailbud fails to move ventrally on the yolk sac after germ ring closure, and the tip of the tail fails to detach from the yolk tube. Mutants in kugelig (kgg) do not form the yolk tube at the posterior side of the yolk sac.

AB - We have identified several genes that are required for various morphogenetic processes during gastrulation and tail formation, Two genes are required in the anterior region of the body axis: one eyed pinhead (oep) and dir ty nose (dns). oep mutant embryos are defective in prechordal plate formation and the specification of anterior and ventral structures of the central nervous system, In dns mutants, cells of the prechordal plate, such as the prospective hatching gland cells, fail to specify. Two genes are required for convergence and extension movements. In mutant trilobite embryos, extension movements on the dorsal side of the embryo are affected, whereas in the formerly described spadetail mutants, for which two new alleles have been isolated, convergent movements of ventrolateral cells to the dorsal side are blocked. Two genes are required for the development of the posterior end of the body axis, In pipetail mutants, the tailbud fails to move ventrally on the yolk sac after germ ring closure, and the tip of the tail fails to detach from the yolk tube. Mutants in kugelig (kgg) do not form the yolk tube at the posterior side of the yolk sac.

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KW - trilobite

KW - tail formation

KW - gastrulation

KW - pipetail

KW - cyclopia

KW - zebrafish

KW - kugelig

KW - one-eyed-pinhead

KW - axis extension

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JF - Development

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