Multiresidue methods for the analysis of pharmaceuticals, personal care products and illicit drugs in surface water and wastewater by solid-phase extraction and ultra performance liquid chromatography-electrospray tandem mass spectrometry

Barbara Kasprzyk-Hordern, R M Dinsdale, A J Guwy

Research output: Contribution to journalArticlepeer-review

240 Citations (Scopus)

Abstract

The main aim of the presented research is to introduce a new technique, ultra performance liquid chromatography-positive/negative electrospray tandem mass spectrometry (UPLC-ESI/MS/MS), for the development of new simultaneous multiresidue methods (over 50 compounds). These methods were used for the determination of multiple classes of pharmaceuticals (acidic, basic and neutral compounds: analgesic/anti-inflammatory drugs, antibiotics, antiepileptics, beta-adrenoceptor blocking drugs, lipid regulating agents, etc.), personal care products (sunscreen agents, preservatives, disinfectant/antiseptics) and illicit drugs (amphetamine, cocaine and benzoylecgonine) in surface water and wastewater. The usage of the novel UPLC system with a 1.7 mu m particle-packed column allowed for good resolution of analytes with the utilisation of low mobile phase flow rates (0.05-0.07 mL min(-1)) and short retention times (method times of up to 25 min), delivering a fast and cost-effective method. SPE with the usage of Oasis MCX strong cation-exchange mixed-mode polymeric sorbent was chosen for sample clean-up and concentration. The influence of mobile phase composition, matrix-assisted ion suppression in ESI-MS and SPE recovery on the sensitivity of the method was extensively studied. The method limits of quantification were at low nanogram per litre levels and ranged from tenths of ng L-1 to tens of ng L-1 in surface water and from single ng L-1 to a few hundreds of ng L-1 in the case of wastewater. The instrumental and method intraday and interday repeatabilities were on average less than 5%. The method was successfully applied for the determination of pharmaceuticals in the River Taff (South Wales) and a wastewater treatment plant (WWTP Cilfy-nydd). Several pharmaceuticals and personal care products were determined in river water at levels ranging from single ng L-1 to single mu g L-1.
Original languageEnglish
Pages (from-to)1293-1308
Number of pages16
JournalAnalytical and Bioanalytical Chemistry
Volume391
Issue number4
DOIs
Publication statusPublished - 2008

Keywords

  • treatment
  • plants
  • ion suppression
  • swiss lakes
  • risk-assessment
  • solid-phase
  • extraction
  • samples
  • wastewaters
  • ultra performance liquid chromatography-tandem mass spectrometry
  • uv filters
  • illicit drugs
  • multiresidue method
  • acidic pharmaceuticals
  • contaminants
  • personal care products
  • active compounds
  • receiving waters
  • pharmaceuticals

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