Multirate delivery of multiple therapeutic agents from metal-organic frameworks

Alistair C. McKinlay, Phoebe K. Allan, Catherine L. Renouf, Morven J. Duncan, Paul S. Wheatley, Stewart J. Warrender, Daniel Dawson, Sharon E. Ashbrook, Barbara Gil, Bartosz Marszalek, Tina Düren, Jennifer J. Williams, Cedric Charrier, Derry K. Mercer, Simon J. Teat, Russell E. Morris

Research output: Contribution to journalArticle

38 Citations (Scopus)
52 Downloads (Pure)

Abstract

The highly porous nature of metal-organic frameworks (MOFs) offers great potential for the delivery of therapeutic agents. Here, we show that highly porous metal-organic frameworks can be used to deliver multiple therapeutic agents - a biologically active gas, an antibiotic drug molecule, and an active metal ion - simultaneously but at different rates. The possibilities offered by delivery of multiple agents with different mechanisms of action and, in particular, variable timescales may allow new therapy approaches. Here, we show that the loaded MOFs are highly active against various strains of bacteria.

Original languageEnglish
Article number124108
JournalAPL Materials
Volume2
Issue number12
Early online dateDec 2014
DOIs
Publication statusPublished - 1 Jan 2015

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)

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  • Cite this

    McKinlay, A. C., Allan, P. K., Renouf, C. L., Duncan, M. J., Wheatley, P. S., Warrender, S. J., Dawson, D., Ashbrook, S. E., Gil, B., Marszalek, B., Düren, T., Williams, J. J., Charrier, C., Mercer, D. K., Teat, S. J., & Morris, R. E. (2015). Multirate delivery of multiple therapeutic agents from metal-organic frameworks. APL Materials, 2(12), [124108]. https://doi.org/10.1063/1.4903290