Multiple phosphatases regulate carbon source-dependent germination and primary metabolism in aspergillus nidulans

Leandro José de Assis, Laure Nicolas Annick Ries, Marcela Savoldi, Taisa Magnani Dinamarco, Gustavo Henrique Goldman, Neil Andrew Brown

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Aspergillus nidulans is an important mold and a model system for the study of fungal cell biology. In addition, invasive A. nidulans pulmonary infections are common in humans with chronic granulomatous disease. The morphological and biochemical transition from dormant conidia into active, growing, filamentous hyphae requires the coordination of numerous biosynthetic, developmental, and metabolic processes. The present study exhibited the diversity of roles performed by seven phosphatases in regulating cell cycle, development, and metabolism in response to glucose and alternative carbon sources. The identified phosphatases highlighted the importance of several signaling pathways regulating filamentous growth, the action of the pyruvate dehydrogenase complex as a metabolic switch controlling carbon usage, and the identification of the key function performed by the α-ketoglutarate dehydrogenase during germination. These novel insights into the fundamental roles of numerous phosphatases in germination and carbon sensing have provided new avenues of research into the identification of inhibitors of fungal germination, with implications for the food, feed, and pharmaceutical industries.

Original languageEnglish
Pages (from-to)857-872
Number of pages16
JournalG3: Genes, Genomes, Genetics
Volume5
Issue number5
DOIs
Publication statusPublished - Mar 2015

Keywords

  • Cell cycle
  • Germination
  • Glucose metabolism
  • Phosphatase

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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