A meta-analysis is provided of research examining the relationship between multidimensional perfectionism and burnout. In doing so, relationships before and after controlling for the relationship between dimensions of perfectionism were examined along with whether relationships were moderated by domain (work, sport, or education). A literature search yielded 43 studies (N = 9838) and 663 effect sizes. Meta-analysis using random-effects models revealed that perfectionistic strivings had small negative or non-significant relationships with overall burnout and symptoms of burnout. By contrast, perfectionistic concerns displayed medium-to-large and medium positive relationships with overall burnout and symptoms of burnout. After controlling for the relationship between dimensions of perfectionism, “pure” perfectionistic strivings displayed notably larger negative relationships. In terms of moderation, in some cases perfectionistic strivings were less adaptive and perfectionistic concerns more maladaptive in the work domain. Future research should examine explanatory mechanisms, adopt longitudinal designs, and develop interventions to reduce perfectionistic concerns fuelled burnout.