Multi-shot Echo Planar Imaging for accelerated Cartesian MR Fingerprinting: an alternative to conventional spiral MR Fingerprinting

Arnold V. J. Benjamin, Pedro A. Gómez, Mohammad Golbabaee, Zaid Mahbub, Tim Sprenger, Marion I. Menzel, Mike Davies, Ian Marshall

Research output: Contribution to journalArticlepeer-review

9 Citations (SciVal)


Purpose: To develop an accelerated Cartesian MRF implementation using a multi-shot EPI sequence for rapid simultaneous quantification of T1 and T2 parameters. Methods: The proposed Cartesian MRF method involved the acquisition of highly subsampled MR images using a 16-shot EPI readout. A linearly varying flip angle train was used for rapid, simultaneous T1 and T2 quantification. The results were compared to a conventional spiral MRF implementation. The acquisition time per slice was 8s and this method was validated on two different phantoms and three healthy volunteer brains in vivo. Results: Joint T1 and T2 estimations using the 16-shot EPI readout are in good agreement with the spiral implementation using the same acquisition parameters (<4% deviation for T1 and <6% deviation for T2). The T1 and T2 values also agree with the conventional values previously reported in the literature. The visual qualities of fine brain structures in the multi-parametric maps generated by multi-shot EPI-MRF and Spiral-MRF implementations were comparable. Conclusion: The multi-shot EPI-MRF method generated accurate quantitative multi-parametric maps similar to conventional Spiral-MRF. This multi-shot approach achieved considerable k-space subsampling and comparatively short TRs in a similar manner to spirals and therefore provides an alternative for performing MRF using an accelerated Cartesian readout; thereby increasing the potential usability of MRF.

Original languageEnglish
Pages (from-to)20-32
Number of pages13
JournalMagnetic Resonance Imaging
Early online date10 May 2019
Publication statusPublished - 1 Sept 2019


  • Cartesian MRF
  • Multi-shot EPI
  • Quantitative maps

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging


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