MSI and EBV Positive Gastric Cancer's Subgroups and Their Link With Novel Immunotherapy

Maria Grazia Rodriquenz; Giandomenico Roviello; Alberto D'Angelo; Daniele Lavacchi; Franco Roviello; Karol Polom

doi:10.3390/jcm9051427

MSI and EBV Positive Gastric Cancer's Subgroups and Their Link With Novel Immunotherapy

Maria Grazia Rodriquenz
, Giandomenico Roviello
, Alberto D'Angelo
, Daniele Lavacchi
, Franco Roviello
, Karol Polom

Department of Life Sciences

IRCCS CROB
University of Florence
Sasol Technology (UK) Ltd
Careggi University Hospital
Università degli Studi di Siena
Gdansk Medical University

Research output: Contribution to journal › Review article › peer-review

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Abstract

Gastric cancers have been historically classified based on histomorphologic features. The Cancer Genome Atlas network reported the comprehensive identification of genetic alterations associated with gastric cancer, identifying four distinct subtypes- Epstein-Barr virus (EBV)-positive, microsatellite-unstable/instability (MSI), genomically stable and chromosomal instability. In particular, EBV-positive and MSI gastric cancers seem responsive to novel immunotherapies drugs. The aim of this review is to describe MSI and EBV positive gastric cancer's subgroups and their relationship with novel immunotherapy.

Original language	English
Article number	1427
Journal	Journal of Clinical Medicine
Volume	9
Issue number	5
DOIs	https://doi.org/10.3390/jcm9051427
Publication status	Published - 11 May 2020

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title = "MSI and EBV Positive Gastric Cancer's Subgroups and Their Link With Novel Immunotherapy",

abstract = "Gastric cancers have been historically classified based on histomorphologic features. The Cancer Genome Atlas network reported the comprehensive identification of genetic alterations associated with gastric cancer, identifying four distinct subtypes- Epstein-Barr virus (EBV)-positive, microsatellite-unstable/instability (MSI), genomically stable and chromosomal instability. In particular, EBV-positive and MSI gastric cancers seem responsive to novel immunotherapies drugs. The aim of this review is to describe MSI and EBV positive gastric cancer's subgroups and their relationship with novel immunotherapy.",

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AU - Rodriquenz, Maria Grazia

AU - Roviello, Giandomenico

AU - D'Angelo, Alberto

AU - Lavacchi, Daniele

AU - Roviello, Franco

AU - Polom, Karol

PY - 2020/5/11

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N2 - Gastric cancers have been historically classified based on histomorphologic features. The Cancer Genome Atlas network reported the comprehensive identification of genetic alterations associated with gastric cancer, identifying four distinct subtypes- Epstein-Barr virus (EBV)-positive, microsatellite-unstable/instability (MSI), genomically stable and chromosomal instability. In particular, EBV-positive and MSI gastric cancers seem responsive to novel immunotherapies drugs. The aim of this review is to describe MSI and EBV positive gastric cancer's subgroups and their relationship with novel immunotherapy.

AB - Gastric cancers have been historically classified based on histomorphologic features. The Cancer Genome Atlas network reported the comprehensive identification of genetic alterations associated with gastric cancer, identifying four distinct subtypes- Epstein-Barr virus (EBV)-positive, microsatellite-unstable/instability (MSI), genomically stable and chromosomal instability. In particular, EBV-positive and MSI gastric cancers seem responsive to novel immunotherapies drugs. The aim of this review is to describe MSI and EBV positive gastric cancer's subgroups and their relationship with novel immunotherapy.

U2 - 10.3390/jcm9051427

DO - 10.3390/jcm9051427

M3 - Review article

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JO - Journal of Clinical Medicine

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MSI and EBV Positive Gastric Cancer's Subgroups and Their Link With Novel Immunotherapy

Abstract

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