MSI and EBV Positive Gastric Cancer's Subgroups and Their Link With Novel Immunotherapy

Maria Grazia Rodriquenz, Giandomenico Roviello, Alberto D'Angelo, Daniele Lavacchi, Franco Roviello, Karol Polom

Research output: Contribution to journalReview article


Gastric cancers have been historically classified based on histomorphologic features. The Cancer Genome Atlas network reported the comprehensive identification of genetic alterations associated with gastric cancer, identifying four distinct subtypes- Epstein-Barr virus (EBV)-positive, microsatellite-unstable/instability (MSI), genomically stable and chromosomal instability. In particular, EBV-positive and MSI gastric cancers seem responsive to novel immunotherapies drugs. The aim of this review is to describe MSI and EBV positive gastric cancer's subgroups and their relationship with novel immunotherapy.

Original languageEnglish
Article number1427
JournalJournal of Clinical Medicine
Issue number5
Publication statusPublished - 11 May 2020

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