MRI-based strain measurements reflect morphological changes following myocardial infarction: A study on the UK Biobank cohort

Doyin Odunmbaku-Mansell, Eva Sammut, V. D. Bruno, Raimondo Ascione, Jonathan C.L. Rodrigues, H S Gill, Katharine Fraser, Andrew Cookson

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Abstract

In a porcine experimental model of myocardial infarction, a localised, layer-specific, circumferential left ventricular strain metric has been shown to indicate chronic changes in ventricular function post-infarction more strongly than ejection fraction. This novel strain metric might therefore provide useful prognostic information clinically. In this study, existing clinical volume indices, global strains, and the novel, layer-specific strain were calculated for a large human cohort to assess variations in ventricular function and morphology with age, sex, and health status. Imaging and health data from the UK Biobank were obtained, including healthy volunteers and those with a history of cardiovascular illness. In total, 710 individuals were analysed and stratified by age, sex and health. Significant differences in all strain metrics were found between healthy and unhealthy populations, as well as between males and females. Significant differences in basal circumferential strain and global circumferential strain were found between healthy males and females, with males having smaller absolute values for both (all (Formula presented.) 0.001). There were significant differences in the functional variables left ventricular ejection fraction, end-systolic volume, end-systolic volume index and mid-ventricular circumferential strain between healthy and unhealthy male cohorts aged 65–74 (all (Formula presented.) 0.001). These results suggest that whilst regional circumferential strains may be useful clinically for assessing cardiovascular health, care must be taken to ensure critical values are indexed correctly to age and sex, due to the differences in these values observed here.

Original languageEnglish
Pages (from-to)102-111
Number of pages10
JournalJournal Of Anatomy
Volume242
Issue number1
Early online date9 Dec 2022
DOIs
Publication statusPublished - 31 Jan 2023

Bibliographical note

EPSRC - Engineering and Physical Sciences Research Council - DTP (1792324)
Great West 4 (GW4) - GW4-AF4-011

Funding Information:
This research has been conducted using the UK Biobank Resource under Application Number 52530. The authors would like to thank Circle Cardiovascular Imaging for providing complimentary access to the CVI42 software for the duration of this project. This work was partially funded by a Great West 4 (GW4) Initiator grant to Ascione (GW4‐AF4‐011). Mansell was supported by an EPSRC DTP (1792324) studentship. Dr J.C.L. Rodrigues declares the following potential sources of conflict of interest: speakers fees ‐ Sanofi, consultancy fees—NHSX, co‐founder and Partner—Heart Lung Health. All other authors report no potential conflicts of interest.

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