Morphinan cyclic imines and pyrrolidines containing a constrained phenyl group: High affinity opioid agonists

Stephen M. Husbands, John W. Lewis

Research output: Contribution to journalArticle

Abstract

A series of morphinan derivatives which are cyclic imines and pyrrolidines containing a constrained phenyl group has been synthesised and tested for their opioid receptor binding affinity. In opioid binding assays the ligands displayed very high affinity particularly for μ receptors and some showed substantial μ selectivity.

Original languageEnglish
Pages (from-to)2969-2974
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume5
Issue number24
DOIs
Publication statusPublished - 21 Dec 1995

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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