Monte Carlo simulation of biospecific interactions between cells and surfaces

John Hubble

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

A theor. model is developed to describe the affinity-mediated interaction of a suspended cell population and a support surface. The model is capable of describing attachment and detachment phenomena, taking account of both bulk and surface effects. Biospecific interactions between cells and planar surfaces are described using a stochastic Monte Carlo simulation that allows the inclusion of a no. of context sensitive rules. The model includes the effects of applied surface shear, ligand and receptor d. and binding kinetics. Simulation results are presented which show that the model is capable of providing a qual. description of exptl. obsd. responses including attachment rate, surface rolling and time dependent increases in strength of attachment. The equations derived are numerically tractable and are easily solved using a microcomputer. [on SciFinder (R)]
Original languageEnglish
Pages (from-to)4465-4474
Number of pages10
JournalChemical Engineering Science
Volume58
Issue number19
Publication statusPublished - 2003

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