Molecular carcinogenesis

Michael Zachariadis, Konstantinos Evangelou, Nikolaos G. Kastrinakis, Panagiota Papanagnou, Vassilis G. Gorgoulis

Research output: Chapter or section in a book/report/conference proceedingChapter or section


Over the last 20 years, the systematic application of molecular methodologies has revealed a series of cellular events that contribute to cancer development. Although it is clear that each tumor type is unique in terms of pathogenesis and progression, carcinogenesis seems to follow some characteristic fundamental principles, including nonlethal genetic damage, clonal expansion of a single transformed cell, as well as alterations in proto-oncogenes and tumor suppressor genes, all presented in a progressive, multistep fashion.

Original languageEnglish
Title of host publicationKey Topics in Surgical Research and Methodology
PublisherSpringer Berlin Heidelberg
Number of pages29
ISBN (Print)9783540719144
Publication statusPublished - 31 Dec 2010

ASJC Scopus subject areas

  • Medicine(all)


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