Molecular carcinogenesis

Michael Zachariadis; Konstantinos Evangelou; Nikolaos G. Kastrinakis; Panagiota Papanagnou; Vassilis G. Gorgoulis

doi:10.1007/978-3-540-71915-1_74

Molecular carcinogenesis

Michael Zachariadis, Konstantinos Evangelou, Nikolaos G. Kastrinakis, Panagiota Papanagnou, Vassilis G. Gorgoulis

National and Kapodistrian University of Athens

Research output: Chapter or section in a book/report/conference proceeding › Chapter or section

Abstract

Over the last 20 years, the systematic application of molecular methodologies has revealed a series of cellular events that contribute to cancer development. Although it is clear that each tumor type is unique in terms of pathogenesis and progression, carcinogenesis seems to follow some characteristic fundamental principles, including nonlethal genetic damage, clonal expansion of a single transformed cell, as well as alterations in proto-oncogenes and tumor suppressor genes, all presented in a progressive, multistep fashion.

Original language	English
Title of host publication	Key Topics in Surgical Research and Methodology
Publisher	Springer Berlin Heidelberg
Pages	975-1003
Number of pages	29
ISBN (Print)	9783540719144
DOIs	https://doi.org/10.1007/978-3-540-71915-1_74
Publication status	Published - 31 Dec 2010

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-3-540-71915-1_74

Cite this

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AU - Zachariadis, Michael

AU - Evangelou, Konstantinos

AU - Kastrinakis, Nikolaos G.

AU - Papanagnou, Panagiota

AU - Gorgoulis, Vassilis G.

PY - 2010/12/31

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AB - Over the last 20 years, the systematic application of molecular methodologies has revealed a series of cellular events that contribute to cancer development. Although it is clear that each tumor type is unique in terms of pathogenesis and progression, carcinogenesis seems to follow some characteristic fundamental principles, including nonlethal genetic damage, clonal expansion of a single transformed cell, as well as alterations in proto-oncogenes and tumor suppressor genes, all presented in a progressive, multistep fashion.

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M3 - Chapter or section

AN - SCOPUS:84895247255

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ER -

Molecular carcinogenesis

Abstract

ASJC Scopus subject areas

UN SDGs

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