Abstract
The invention relates to compounds capable of modulating the permeability of junctions between epithelial cells, and their use to facilitate delivery of substances such as therapeutic and diagnostic agents across epithelial surfaces. In particular the invention relates to the identification of key amino acids in the known permeation enhancer PIP250 and the provision of new permeation enhancing peptides with more transient activity, thus providing faster epithelial recovery
Original language | English |
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Patent number | WO2021250260 |
IPC | A61K38/04,A61K38/16,A61P43/00 |
Priority date | 12/06/20 |
Publication status | Published - 16 Dec 2021 |