MODULATORS OF TIGHT JUNCTION PERMEABILITY

Randy Mrsny (Inventor), Alistair Taverner (Inventor), Khaled Almansour (Inventor)

Research output: Patent

Abstract

The invention relates to compounds capable of modulating the permeability of junctions between epithelial cells, and their use to facilitate delivery of substances such as therapeutic and diagnostic agents across epithelial surfaces. In particular the invention relates to the identification of key amino acids in the known permeation enhancer PIP250 and the provision of new permeation enhancing peptides with more transient activity, thus providing faster epithelial recovery

Original languageEnglish
Patent numberWO2021250260
IPCA61K38/04,A61K38/16,A61P43/00
Priority date12/06/20
Publication statusPublished - 16 Dec 2021

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