Modulation of aerosol clouds produced by pressurised inhalation aerosols

G. Brambilla; D. Ganderton; R. Garzia; D. Lewis; B. Meakin; P. Ventura

doi:10.1016/S0378-5173(99)00137-4

Modulation of aerosol clouds produced by pressurised inhalation aerosols

G. Brambilla, D. Ganderton, R. Garzia, D. Lewis, B. Meakin, P. Ventura

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

76 Citations (SciVal)

Abstract

The inclusion of non-volatile components such as glycerol or polyethylene glycol in hydrofluoralkane (HFA) solution formulations for pressurised metered dose inhalers (pMDIs), greatly increases the particle size of the aerosol. Cloud characteristics can be further modulated by permuting this factor with the choice of propellant and the dimensions of the actuator, to give a chosen fine particle dose and particle diameter. This principle has been used to design solutions which closely match the performance of chlorofluorocarbon based suspension formulations containing beclomethasone dipropionate, budesonide and ipratropium bromide as assessed for pharmaceutical equivalence using the Andersen Cascade impactor.

Original language	English
Pages (from-to)	53-61
Number of pages	9
Journal	International Journal of Pharmaceutics
Volume	186
Issue number	1
DOIs	https://doi.org/10.1016/S0378-5173(99)00137-4
Publication status	Published - 10 Sept 1999

Keywords

Aerosols
Chlorofluorocarbons
Hydrocarbons, Fluorinated
Nebulizers and Vaporizers

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10.1016/S0378-5173(99)00137-4

Cite this

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AU - Ganderton, D.

AU - Garzia, R.

AU - Lewis, D.

AU - Meakin, B.

AU - Ventura, P.

PY - 1999/9/10

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KW - Aerosols

KW - Chlorofluorocarbons

KW - Hydrocarbons, Fluorinated

KW - Nebulizers and Vaporizers

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Modulation of aerosol clouds produced by pressurised inhalation aerosols

Abstract

Keywords

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