Modular fluorescence sensors for saccharides

Susumu Arimori, Michael L. Bell, Chan S. Oh, Karine A. Frimat, Tony D. James

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Modular photoinduced electron transfer (PET) sensors bearing two phenylboronic acid groups, a pyrene group and alkylene linkers, from trimethylene to octamethylene, have been prepared and evaluated. The diboronic acid systems with tetramethylene 34 pentamethylene 35 and hexamethylene 36 linkers display the greatest enhancement in binding relative to monoboronic acid 4 with D-glucose. The diboronic acid system with the hexamethylene 36 linker is particularly D-glucose selective and sensitive. Whilst the diboronic acid systems with the longer heptamethylene 37 and octamethylene 38 linkers display the greatest enhancement in binding relative to monoboronic acid 4 with D-galactose. All saccharide titrations were performed in methanolic aqueous solution.
Original languageEnglish
Pages (from-to)803-808
Number of pages6
JournalJournal of the Chemical Society, Perkin Transactions 1
Volume2002
Issue number6
Early online date18 Feb 2002
DOIs
Publication statusPublished - 2002

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