Abstract
OBJECTIVES: To investigate associations between obesity, changes in body mass index (BMI), alcohol intake and smoking status and the development of Psoriatic Arthritis (PsA) in people with psoriasis.
METHODS: We have undertaken a cohort study involving incident psoriasis cases identified from the UK Clinical Practice Research Datalink between 1998 and 2014. The associations between smoking, alcohol and BMI and development of PsA were assessed using generalised additive models. Additionally, the risks associated with a change in BMI during follow-up were investigated using distributed lag non-linear models.
RESULTS: We identified 90,189 incident cases of psoriasis (42% males, mean age 51) of whom 1,409 had a subsequent record of PsA diagnosis. BMIs of 25.0-29.9, 30.0-34.9 and ≥35.0 were significantly associated with an increased risk of developing PsA compared to BMIs of <25.0: ORadj 1.79 (CI95 1.46 - 2.19), ORadj 2.10 (CI95 1.67 - 2.63), and ORadj 2.68 (CI95 2.09 - 3.43), respectively. Reducing BMI over a 10-year period (linearly) was associated with a reduction in the risk of developing PsA when compared to BMI remaining constant over the same period. Increased risks of developing PsA were associated with moderate drinking but not with ex- or heavy drinking or with current or past smoker status.
CONCLUSION: In this incident psoriasis cohort, increased BMI and moderate drinking but not heavy drinking or smoking status were associated with an increased risk of PsA in people with psoriasis. Importantly, we have shown that reducing weight may result in a reduction in the risk of developing PsA. This article is protected by copyright. All rights reserved.
| Original language | English |
|---|---|
| Journal | British Journal of Dermatology |
| Early online date | 18 Jun 2019 |
| DOIs | |
| Publication status | E-pub ahead of print - 18 Jun 2019 |
Cite this
Modifiable risk factors and the development of psoriatic arthritis in people with psoriasis. / PROMPT Study Group.
In: British Journal of Dermatology, 18.06.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Modifiable risk factors and the development of psoriatic arthritis in people with psoriasis
AU - PROMPT Study Group
AU - Green, A
AU - Shaddick, G
AU - Charlton, R
AU - Snowball, J
AU - Nightingale, A
AU - Smith, C
AU - Tillett, W
AU - McHugh, N
N1 - This article is protected by copyright. All rights reserved.
PY - 2019/6/18
Y1 - 2019/6/18
N2 - OBJECTIVES: To investigate associations between obesity, changes in body mass index (BMI), alcohol intake and smoking status and the development of Psoriatic Arthritis (PsA) in people with psoriasis.METHODS: We have undertaken a cohort study involving incident psoriasis cases identified from the UK Clinical Practice Research Datalink between 1998 and 2014. The associations between smoking, alcohol and BMI and development of PsA were assessed using generalised additive models. Additionally, the risks associated with a change in BMI during follow-up were investigated using distributed lag non-linear models.RESULTS: We identified 90,189 incident cases of psoriasis (42% males, mean age 51) of whom 1,409 had a subsequent record of PsA diagnosis. BMIs of 25.0-29.9, 30.0-34.9 and ≥35.0 were significantly associated with an increased risk of developing PsA compared to BMIs of <25.0: ORadj 1.79 (CI95 1.46 - 2.19), ORadj 2.10 (CI95 1.67 - 2.63), and ORadj 2.68 (CI95 2.09 - 3.43), respectively. Reducing BMI over a 10-year period (linearly) was associated with a reduction in the risk of developing PsA when compared to BMI remaining constant over the same period. Increased risks of developing PsA were associated with moderate drinking but not with ex- or heavy drinking or with current or past smoker status.CONCLUSION: In this incident psoriasis cohort, increased BMI and moderate drinking but not heavy drinking or smoking status were associated with an increased risk of PsA in people with psoriasis. Importantly, we have shown that reducing weight may result in a reduction in the risk of developing PsA. This article is protected by copyright. All rights reserved.
AB - OBJECTIVES: To investigate associations between obesity, changes in body mass index (BMI), alcohol intake and smoking status and the development of Psoriatic Arthritis (PsA) in people with psoriasis.METHODS: We have undertaken a cohort study involving incident psoriasis cases identified from the UK Clinical Practice Research Datalink between 1998 and 2014. The associations between smoking, alcohol and BMI and development of PsA were assessed using generalised additive models. Additionally, the risks associated with a change in BMI during follow-up were investigated using distributed lag non-linear models.RESULTS: We identified 90,189 incident cases of psoriasis (42% males, mean age 51) of whom 1,409 had a subsequent record of PsA diagnosis. BMIs of 25.0-29.9, 30.0-34.9 and ≥35.0 were significantly associated with an increased risk of developing PsA compared to BMIs of <25.0: ORadj 1.79 (CI95 1.46 - 2.19), ORadj 2.10 (CI95 1.67 - 2.63), and ORadj 2.68 (CI95 2.09 - 3.43), respectively. Reducing BMI over a 10-year period (linearly) was associated with a reduction in the risk of developing PsA when compared to BMI remaining constant over the same period. Increased risks of developing PsA were associated with moderate drinking but not with ex- or heavy drinking or with current or past smoker status.CONCLUSION: In this incident psoriasis cohort, increased BMI and moderate drinking but not heavy drinking or smoking status were associated with an increased risk of PsA in people with psoriasis. Importantly, we have shown that reducing weight may result in a reduction in the risk of developing PsA. This article is protected by copyright. All rights reserved.
U2 - 10.1111/bjd.18227
DO - 10.1111/bjd.18227
M3 - Article
JO - British Journal of Dermatology
JF - British Journal of Dermatology
SN - 0007-0963
ER -