Lab-on-a-chip technology has enabled the development of disruptive detection and analysis methods for life sciences and beyond. The miniaturization of existing (and sometimes well established) analysis techniques within microfluidic devices has the potential of resulting in the development of inexpensive, user-friendly and portable devices. This has been the case with ions detection from liquid samples, including water or biological samples like urine, blood and sweat, to name a few. We provide a critical review on recent microfluidic approaches for measurement of ions using microfluidic devices, covering sample treatment (pre-concentration and separation), various ion chelating mechanisms (immunoassay, nucleic acid and chemical chelating) and varying ion detection strategies (optical, electrochemical and colorimetric). It identified areas of development and opportunities mostly in water quality and environment monitoring but also in healthcare diagnostic testing, including detection with smartphones and wearable microfluidic devices.

Original languageEnglish
Article number106845
JournalMicrochemical Journal
Early online date20 Sept 2021
Publication statusPublished - 31 Dec 2021


  • Electrochemical detection
  • Ion chelating
  • Ion determination
  • Microfluidic chip
  • Optical detection
  • Pre-treatment

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy


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