TY - JOUR
T1 - Modern microfluidic approaches for determination of ions
AU - Shi, Huanhuan
AU - Jiang, Shaofeng
AU - Liu, Bo
AU - Liu, Zhengchun
AU - Reis, Nuno M.
N1 - Funding Information:
This work was supported financially by the National Natural Science Foundation of China (Grant No. 62101231 , 61771493 ), the Jiangxi Provincial Natural Science Foundation, China (Grant No. 20202BABL212003 ), the Science and Technology Project of Education Department of Jiangxi Province of China (Grant No. GJJ190510 ) and PhD Research Startup Fund of Nanchang Hangkong University (No. EA202008205 ).
PY - 2021/12/31
Y1 - 2021/12/31
N2 - Lab-on-a-chip technology has enabled the development of disruptive detection and analysis methods for life sciences and beyond. The miniaturization of existing (and sometimes well established) analysis techniques within microfluidic devices has the potential of resulting in the development of inexpensive, user-friendly and portable devices. This has been the case with ions detection from liquid samples, including water or biological samples like urine, blood and sweat, to name a few. We provide a critical review on recent microfluidic approaches for measurement of ions using microfluidic devices, covering sample treatment (pre-concentration and separation), various ion chelating mechanisms (immunoassay, nucleic acid and chemical chelating) and varying ion detection strategies (optical, electrochemical and colorimetric). It identified areas of development and opportunities mostly in water quality and environment monitoring but also in healthcare diagnostic testing, including detection with smartphones and wearable microfluidic devices.
AB - Lab-on-a-chip technology has enabled the development of disruptive detection and analysis methods for life sciences and beyond. The miniaturization of existing (and sometimes well established) analysis techniques within microfluidic devices has the potential of resulting in the development of inexpensive, user-friendly and portable devices. This has been the case with ions detection from liquid samples, including water or biological samples like urine, blood and sweat, to name a few. We provide a critical review on recent microfluidic approaches for measurement of ions using microfluidic devices, covering sample treatment (pre-concentration and separation), various ion chelating mechanisms (immunoassay, nucleic acid and chemical chelating) and varying ion detection strategies (optical, electrochemical and colorimetric). It identified areas of development and opportunities mostly in water quality and environment monitoring but also in healthcare diagnostic testing, including detection with smartphones and wearable microfluidic devices.
KW - Electrochemical detection
KW - Ion chelating
KW - Ion determination
KW - Microfluidic chip
KW - Optical detection
KW - Pre-treatment
UR - http://www.scopus.com/inward/record.url?scp=85118834080&partnerID=8YFLogxK
U2 - 10.1016/j.microc.2021.106845
DO - 10.1016/j.microc.2021.106845
M3 - Review article
AN - SCOPUS:85118834080
SN - 0026-265X
VL - 171
JO - Microchemical Journal
JF - Microchemical Journal
M1 - 106845
ER -