Moderators of response to cognitive behavioural therapy as an adjunct to pharmacotherapy for treatment-resistant depression in primary care

Katherine S Button, Nicholas Turner, John Campbell, David Kessler, Willem Kuyken, Glyn Lewis, Tim J Peters, Laura Thomas, Nicola Wiles

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

BACKGROUND: Stratified medicine aims to improve clinical and cost-effectiveness by identifying moderators of treatment that indicate differential response to treatment. Cognitive behavioural therapy (CBT) is often offered as a 'next-step' for patients who have not responded to antidepressants, but no research has examined moderators of response to CBT in this population. We aimed, therefore, to identify moderators of response to CBT in treatment resistant depression.

METHODS: We used linear regression to test for interactions between treatment effect and 14 putative moderator variables using data from the CoBalT randomised controlled trial. This trial examined the effectiveness of CBT given in addition to usual care (n=234) compared with usual care alone (n=235) for primary care patients with treatment resistant depression.

RESULTS: Age was the only variable with evidence for effect modification (p Value for interaction term=0.012), with older patients benefiting the most from CBT. We found no evidence of effect modification by any other demographic, life, illness, personality trait, or cognitive variable (p≥0.2).

CONCLUSIONS: Given the largely null findings, a stratified approach that might limit offering CBT is premature; CBT should be offered to all individuals where antidepressant medication has failed.

LanguageEnglish
Pages272-80
Number of pages9
JournalJournal of Affective Disorders
Volume174
Early online date6 Dec 2014
DOIs
StatusPublished - 15 Mar 2015

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Treatment-Resistant Depressive Disorder
Cognitive Therapy
Primary Health Care
Drug Therapy
Antidepressive Agents
Epidemiologic Effect Modifiers
Cobalt
Cost-Benefit Analysis
Personality
Linear Models
Therapeutics
Randomized Controlled Trials
Medicine
Demography
Research

Keywords

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Antidepressive Agents
  • Cognition
  • Cognitive Therapy
  • Combined Modality Therapy
  • Cost-Benefit Analysis
  • Depressive Disorder, Treatment-Resistant
  • Female
  • Humans
  • Male
  • Middle Aged
  • Personality
  • Primary Health Care
  • Treatment Outcome
  • Young Adult

Cite this

Moderators of response to cognitive behavioural therapy as an adjunct to pharmacotherapy for treatment-resistant depression in primary care. / Button, Katherine S; Turner, Nicholas; Campbell, John; Kessler, David; Kuyken, Willem; Lewis, Glyn; Peters, Tim J; Thomas, Laura; Wiles, Nicola.

In: Journal of Affective Disorders, Vol. 174, 15.03.2015, p. 272-80.

Research output: Contribution to journalArticle

Button, Katherine S ; Turner, Nicholas ; Campbell, John ; Kessler, David ; Kuyken, Willem ; Lewis, Glyn ; Peters, Tim J ; Thomas, Laura ; Wiles, Nicola. / Moderators of response to cognitive behavioural therapy as an adjunct to pharmacotherapy for treatment-resistant depression in primary care. In: Journal of Affective Disorders. 2015 ; Vol. 174. pp. 272-80.
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