Modelling natural burst firing in nigral dopamine neurons

M S Penney, N F Britton

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The natural burst firing observed in vivo in mesolimbic dopamine neurons is of great significance regarding these neurons' involvement in response to sensory stimuli associated with primary reward. The cellular mechanisms underlying a natural burst have been experimentally characterized previously and hypothesized to be caused by a calcium-sensitive inactivation of a potassium channel. We present a mathematical model of a mesolimbic neuron that demonstrates how such a mechanism can produce realistic bursting patterns, but only A hen combined with an appropriately timed membrane depolarization from an external source.
Original languageEnglish
Pages (from-to)207-223
Number of pages17
JournalJournal of Theoretical Biology
Volume219
Issue number2
Publication statusPublished - 2002

Fingerprint

Dopaminergic Neurons
Substantia Nigra
dopamine
Burst
Neurons
Neuron
Dopamine
neurons
Potassium Channels
Reward
Modeling
Depolarization
Theoretical Models
Bursting
potassium channels
Calcium
Membranes
Potassium
hens
inactivation

Cite this

Modelling natural burst firing in nigral dopamine neurons. / Penney, M S; Britton, N F.

In: Journal of Theoretical Biology, Vol. 219, No. 2, 2002, p. 207-223.

Research output: Contribution to journalArticle

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