Modelling natural burst firing in nigral dopamine neurons

M S Penney, N F Britton

Research output: Contribution to journalArticlepeer-review

5 Citations (SciVal)


The natural burst firing observed in vivo in mesolimbic dopamine neurons is of great significance regarding these neurons' involvement in response to sensory stimuli associated with primary reward. The cellular mechanisms underlying a natural burst have been experimentally characterized previously and hypothesized to be caused by a calcium-sensitive inactivation of a potassium channel. We present a mathematical model of a mesolimbic neuron that demonstrates how such a mechanism can produce realistic bursting patterns, but only A hen combined with an appropriately timed membrane depolarization from an external source.
Original languageEnglish
Pages (from-to)207-223
Number of pages17
JournalJournal of Theoretical Biology
Issue number2
Publication statusPublished - 2002


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