Model-based super-resolution reconstruction of T2 maps

Wajiha Bano, Gian Franco Piredda, Mike Davies, Ian Marshall, Mohammad Golbabaee, Reto Meuli, Tobias Kober, Jean-Philippe Thiran, Tom Hilbert

Research output: Contribution to journalArticlepeer-review

13 Citations (SciVal)


Purpose: High-resolution isotropic T 2 mapping of the human brain with multi-echo spin-echo (MESE) acquisitions is challenging. When using a 2D sequence, the resolution is limited by the slice thickness. If used as a 3D acquisition, specific absorption rate limits are easily exceeded due to the high power deposition of nonselective refocusing pulses. A method to reconstruct 1-mm 3 isotropic T 2 maps is proposed based on multiple 2D MESE acquisitions. Data were undersampled (10-fold) to compensate for the prolonged scan time stemming from the super-resolution acquisition. Theory and Methods: The proposed method integrates a classical super-resolution with an iterative model-based approach to reconstruct quantitative maps from a set of undersampled low-resolution data. The method was tested on numerical and multipurpose phantoms, and in vivo data. T 2 values were assessed with a region-of-interest analysis using a single-slice spin-echo and a fully sampled MESE acquisition in a phantom, and a MESE acquisition in healthy volunteers. Results: Numerical simulations showed that the best trade-off between acceleration and number of low-resolution datasets is 10-fold acceleration with 4 acquisitions (acquisition time = 18 min). The proposed approach showed improved resolution over low-resolution images for both phantom and brain. Region-of-interest analysis of the phantom compartments revealed that at shorter T 2, the proposed method was comparable with the fully sampled MESE. For the volunteer data, the T 2 values found in the brain structures were consistent across subjects (8.5-13.1 ms standard deviation). Conclusion: The proposed method addresses the inherent limitations associated with high-resolution T 2 mapping and enables the reconstruction of 1 mm 3 isotropic relaxation maps with a 10 times faster acquisition.

Original languageEnglish
Pages (from-to)906-919
Number of pages14
JournalMagnetic Resonance in Medicine
Issue number3
Early online date13 Sept 2019
Publication statusPublished - 1 Mar 2020


  • T mapping
  • model-based reconstruction
  • parallel Imaging
  • super-resolution

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Model-based super-resolution reconstruction of T2 maps'. Together they form a unique fingerprint.

Cite this