Projects per year
Abstract
Vitamin D is lipophilic and accumulates substantially in adipose tissue. Even without supplementation, the amount of vitamin D in the adipose of a typical adult is equivalent to several months of the daily reference nutrient intake (RNI). Paradoxically, despite the large amounts of vitamin D located in adipose tissue, individuals with obesity are often vitamin D deficient according to consensus measures of vitamin D status (serum 25‐hydroxyvitamin D concentrations). Thus, it appears that vitamin D can become ‘trapped’ in adipose tissue, potentially due to insufficient lipolytic stimulation and/or due to tissue dysfunction/adaptation resulting from adipose expansion. Emerging evidence suggests that exercise may mobilise vitamin D from adipose (even in the absence of weight loss). If exercise helps to mobilise vitamin D from adipose tissue, then this could have important ramifications for practitioners and policymakers regarding the management of low circulating levels of vitamin D, as well as chronically low levels of physical activity, obesity and associated health conditions. This perspective led us to design a study to examine the impact of exercise on vitamin D status, vitamin D turnover and adipose tissue vitamin D content (the VitaDEx project). The VitaDEx project will determine whether increasing physical activity (via exercise) represents a potentially useful strategy to mobilise vitamin D from adipose tissue.
Original language | English |
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Pages (from-to) | 25-35 |
Number of pages | 11 |
Journal | Nutrition Bulletin |
Volume | 44 |
Issue number | 1 |
Early online date | 3 Feb 2019 |
DOIs | |
Publication status | Published - 1 Mar 2019 |
Keywords
- 25(OH)D
- 25-hydroxyvitamin D
- adipose
- exercise
- physical activity
- vitamin D
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics
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Dive into the research topics of 'Mobilising vitamin D from adipose tissue: The potential impact of exercise'. Together they form a unique fingerprint.Projects
- 1 Finished
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Mobilising Vitamin D Sequestered In Adipose Tissue In Humans
Thompson, D. (PI), Betts, J. (CoI) & Gonzalez, J. (CoI)
Biotechnology and Biological Sciences Research Council
11/10/18 → 10/01/23
Project: Research council