Abstract
We explore a novel microfluidic approach for assays without sample preparation which can revolutionize point-of-care diagnostics industry due to its simplicity and affordability. This studies aims at understanding the role of surface coverage and diffusion distance in antibody-antigen equilibrium in Teflon-FEP microcapillaries. IL-1β human cytokine sandwich assay showed higher surface coverages in ∼200 μm diameter microcapillaries eliminating biological matrix effect interference, being highly desirable for rapid point-of-care (POC) tests.
| Original language | English |
|---|---|
| Title of host publication | 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 |
| Place of Publication | Dublin, Ireland |
| Publisher | Chemical and Biological Microsystems Society |
| Pages | 1238-1239 |
| Number of pages | 2 |
| ISBN (Electronic) | 9780979806490 |
| Publication status | Published - 1 Jan 2016 |
| Event | 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 - Dublin, Ireland Duration: 9 Oct 2016 → 13 Oct 2016 |
Conference
| Conference | 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 |
|---|---|
| Country/Territory | Ireland |
| City | Dublin |
| Period | 9/10/16 → 13/10/16 |
Keywords
- Diagnostics
- Matrix effect
- Microcapillaries
- Surface coverage
- Teflon-FEP
ASJC Scopus subject areas
- Control and Systems Engineering