TY - JOUR
T1 - Microemulsions for topical delivery of 8-methoxsalen
AU - Baroli, Bianca
AU - López-Quintela, M. Arturo
AU - Delgado-Charro, M.Begoña
AU - Fadda, Anna M.
AU - Blanco-Méndez, José
PY - 2000/10/3
Y1 - 2000/10/3
N2 - 8-Methoxsalen (8-MOP) and related furocumarins have been extensively used for the treatment of hyperproliferative skin diseases in association with long-wavelength UVA light. In order to develop alternative formulations for the topical administration of 8-MOP, microemulsions were evaluated as delivery vehicles. Six microemulsion formulations were prepared using water, isopropyl myristate (IPM) and Tween(®) 80: Span(®) 80: 1,2-Octanediol (3:1:1.2 w/w). The microemulsions were characterized using conductimetric and dynamic light scattering analyses. The ability of the systems to deliver 8-MOP into and through the skin was evaluated in vitro using newborn pig-skin. The in vitro permeation data showed that the novel microemulsions increased the 8-MOP total penetration through the skin by order of 1.9-4.5, as compared with IPM. In general, the accumulation of 8-MOP into the skin was increased by a factor of 1.5-4.5 by the microemulsion systems with respect to their total amount of drug delivered across the skin. These results suggest that the studied microemulsion systems may be appropriate vehicles for the topical delivery of 8-MOP. Copyright (C) 2000 Elsevier Science B.V.
AB - 8-Methoxsalen (8-MOP) and related furocumarins have been extensively used for the treatment of hyperproliferative skin diseases in association with long-wavelength UVA light. In order to develop alternative formulations for the topical administration of 8-MOP, microemulsions were evaluated as delivery vehicles. Six microemulsion formulations were prepared using water, isopropyl myristate (IPM) and Tween(®) 80: Span(®) 80: 1,2-Octanediol (3:1:1.2 w/w). The microemulsions were characterized using conductimetric and dynamic light scattering analyses. The ability of the systems to deliver 8-MOP into and through the skin was evaluated in vitro using newborn pig-skin. The in vitro permeation data showed that the novel microemulsions increased the 8-MOP total penetration through the skin by order of 1.9-4.5, as compared with IPM. In general, the accumulation of 8-MOP into the skin was increased by a factor of 1.5-4.5 by the microemulsion systems with respect to their total amount of drug delivered across the skin. These results suggest that the studied microemulsion systems may be appropriate vehicles for the topical delivery of 8-MOP. Copyright (C) 2000 Elsevier Science B.V.
KW - Methoxsalen
KW - Microemulsions
KW - Permeation enhancer
KW - Psoriasis
KW - Topical delivery
UR - http://www.scopus.com/inward/record.url?scp=0342472123&partnerID=8YFLogxK
UR - https://doi.org/10.1016/S0168-3659(00)00309-6
U2 - 10.1016/S0168-3659(00)00309-6
DO - 10.1016/S0168-3659(00)00309-6
M3 - Article
C2 - 11018558
AN - SCOPUS:0342472123
SN - 0168-3659
VL - 69
SP - 209
EP - 218
JO - Journal of Controlled Release
JF - Journal of Controlled Release
IS - 1
ER -