Microcontact printing of lipophilic self-assembled monolayers for the attachment of biomimetic lipid bilayers to surfaces

A. Toby A Jenkins, Neville Boden, Richard J. Bushby, Stephen D. Evans, Peter F. Knowles, Robert E. Miles, Simon D. Ogier, Holger Schönherr, G. Julius Vancso

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Abstract

This paper presents a novel method for supporting planar lipid bilayers using microcontact printed lipophilic self-assembled monolayers, in such a way as to retain their capacity to support biological functionality. Impedance spectroscopy, surface plasmon resonance, and atomic force microscopy are used to monitor the formation and investigate the properties of the supported bilayers. In addition, we show that the antibiotic peptide gramicidin and the ionophore valinomycin exhibit the expected ion selectivity. Finally, scanning force microscopy measurements show surface friction changes following bilayer formation. Chemically modified tips were used to obtain information about both the energy of the surface (hydrophobic/hydrophilic nature) and the mechanical properties of the surface.

Original languageEnglish
Pages (from-to)5274-5280
Number of pages7
JournalJournal of the American Chemical Society
Volume121
Issue number22
Early online date22 May 1999
DOIs
Publication statusPublished - 1 Jun 1999

ASJC Scopus subject areas

  • Chemistry(all)

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