TY - GEN
T1 - Microcirculation of Blood and Interstitial Fluid in a Poroelastic Model of the Liver
AU - Argungu, Maryam
AU - Tweedy, Jennifer H.
PY - 2017/7/6
Y1 - 2017/7/6
N2 - Cirrhosis is a life-threatening condition that represents a leading cause of death in the western world. In this condition the structure of the liver tissue is altered by the development of fibrosis, which means it becomes stiffer and its permeability to blood and interstitial flow within the tissue that are vital to its function are reduced. We develop a new mathematical model based on those, which we use to investigate the changes in liver volume, blood flow and lymphatic uptake, which measures interstitial flow, that occur as the tissue becomes progressively stiffer. Our results suggest that the typical changes that develop during cirrhosis have a significant effect on the permeability properties, highlighting the seriousness of this condition.
AB - Cirrhosis is a life-threatening condition that represents a leading cause of death in the western world. In this condition the structure of the liver tissue is altered by the development of fibrosis, which means it becomes stiffer and its permeability to blood and interstitial flow within the tissue that are vital to its function are reduced. We develop a new mathematical model based on those, which we use to investigate the changes in liver volume, blood flow and lymphatic uptake, which measures interstitial flow, that occur as the tissue becomes progressively stiffer. Our results suggest that the typical changes that develop during cirrhosis have a significant effect on the permeability properties, highlighting the seriousness of this condition.
UR - http://www.scopus.com/inward/record.url?scp=85026286340&partnerID=8YFLogxK
U2 - 10.1061/9780784480779.140
DO - 10.1061/9780784480779.140
M3 - Chapter in a published conference proceeding
T3 - Poromechanics 2017 - Proceedings of the 6th Biot Conference on Poromechanics
SP - 1126
EP - 1134
BT - Poromechanics 2017 - Proceedings of the 6th Biot Conference on Poromechanics
A2 - Dangla, Patrick
A2 - Pereira, Jean-Michel
A2 - Ghabezloo, Siavash
A2 - Vandamme, Matthieu
PB - American Society of Civil Engineers (ASCE)
T2 - 6th Biot Conference on Poromechanics, Poromechanics 2017
Y2 - 9 July 2017 through 13 July 2017
ER -