Microcirculation of Blood and Interstitial Fluid in a Poroelastic Model of the Liver

Maryam Argungu, Jennifer H. Tweedy

Research output: Chapter or section in a book/report/conference proceedingChapter in a published conference proceeding

1 Citation (SciVal)

Abstract

Cirrhosis is a life-threatening condition that represents a leading cause of death in the western world. In this condition the structure of the liver tissue is altered by the development of fibrosis, which means it becomes stiffer and its permeability to blood and interstitial flow within the tissue that are vital to its function are reduced. We develop a new mathematical model based on those, which we use to investigate the changes in liver volume, blood flow and lymphatic uptake, which measures interstitial flow, that occur as the tissue becomes progressively stiffer. Our results suggest that the typical changes that develop during cirrhosis have a significant effect on the permeability properties, highlighting the seriousness of this condition.

Original languageEnglish
Title of host publicationPoromechanics 2017 - Proceedings of the 6th Biot Conference on Poromechanics
EditorsPatrick Dangla, Jean-Michel Pereira, Siavash Ghabezloo, Matthieu Vandamme
PublisherAmerican Society of Civil Engineers (ASCE)
Pages1126-1134
Number of pages9
ISBN (Electronic)9780784480779
DOIs
Publication statusPublished - 6 Jul 2017
Event6th Biot Conference on Poromechanics, Poromechanics 2017 - Paris, France
Duration: 9 Jul 201713 Jul 2017

Publication series

NamePoromechanics 2017 - Proceedings of the 6th Biot Conference on Poromechanics

Conference

Conference6th Biot Conference on Poromechanics, Poromechanics 2017
Country/TerritoryFrance
CityParis
Period9/07/1713/07/17

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Mechanics of Materials
  • Acoustics and Ultrasonics

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