Microbial alkene epoxidation-merits and limitations

A. N. Onumonu, A. Colocoussi, C. Matthews, M. P. Woodland, D. J. Leak

Research output: Contribution to journalArticlepeer-review


The direct epoxidation of olefins using monooxygenases offers the realistic prospect of stoichiometric conversion of a pro-chiral substrate into an enantiomerically pure product. A number of microbial systems are available in which the mechanism of oxygen activation, and consequently the oxygen reactivity, differs. This paper discusses some of the merits and potential problems associated with these different systems.

Original languageEnglish
Pages (from-to)211-218
Number of pages8
JournalBiocatalysis and Biotransformation
Issue number1-4
Publication statusPublished - 1 Jan 1994


  • Alkane monooxygenase
  • Alkene monooxygenase
  • Epoxide
  • Microbial oxidation

ASJC Scopus subject areas

  • Biotechnology
  • Catalysis
  • Biochemistry


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