Micellar chromatographic determination of partition coefficients and associated thermodynamic data for pharmaceutical compounds

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Abstract

Micelle/water partition coefficients were obtained for procaine hydrochloride using micellar liquid chromatography (MLC) to illustrate the potential application of this technique to compounds of pharmaceutical interest. Experiments were conducted over a temperature range which led to calculation of a Gibbs free energy, enthalpy and entropy of transfer for procaine hydrochloride. Successful application of this technique was confirmed using a second compound over a range of temperatures, namely caffeine. Overall, this work confirms that MLC can be used to determine precise and accurate partition coefficients that possibly more closely mimic biological membranes than traditional in vitro systems, namely octanol/water.
Original languageEnglish
Pages (from-to)343-347
Number of pages5
JournalJournal of Thermal Analysis and Calorimetry
Volume102
Issue number1
DOIs
Publication statusPublished - 2010

Keywords

  • systems
  • model
  • penetration
  • Micelle
  • local-anesthetics
  • octanol-water
  • Procaine
  • MLC
  • sodium
  • hplc
  • performance liquid-chromatography
  • Partition coefficient
  • Caffeine

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