Micellar chromatographic determination of partition coefficients and associated thermodynamic data for pharmaceutical compounds

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7 Citations (Scopus)

Abstract

Micelle/water partition coefficients were obtained for procaine hydrochloride using micellar liquid chromatography (MLC) to illustrate the potential application of this technique to compounds of pharmaceutical interest. Experiments were conducted over a temperature range which led to calculation of a Gibbs free energy, enthalpy and entropy of transfer for procaine hydrochloride. Successful application of this technique was confirmed using a second compound over a range of temperatures, namely caffeine. Overall, this work confirms that MLC can be used to determine precise and accurate partition coefficients that possibly more closely mimic biological membranes than traditional in vitro systems, namely octanol/water.
Original languageEnglish
Pages (from-to)343-347
Number of pages5
JournalJournal of Thermal Analysis and Calorimetry
Volume102
Issue number1
DOIs
Publication statusPublished - 2010

Fingerprint

Procaine
Liquid chromatography
liquid chromatography
hydrochlorides
partitions
Thermodynamics
Biological membranes
caffeine
Octanols
thermodynamics
Water
Micelles
Gibbs free energy
coefficients
Caffeine
Pharmaceutical Preparations
water
Enthalpy
micelles
Entropy

Keywords

  • systems
  • model
  • penetration
  • Micelle
  • local-anesthetics
  • octanol-water
  • Procaine
  • MLC
  • sodium
  • hplc
  • performance liquid-chromatography
  • Partition coefficient
  • Caffeine

Cite this

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title = "Micellar chromatographic determination of partition coefficients and associated thermodynamic data for pharmaceutical compounds",
abstract = "Micelle/water partition coefficients were obtained for procaine hydrochloride using micellar liquid chromatography (MLC) to illustrate the potential application of this technique to compounds of pharmaceutical interest. Experiments were conducted over a temperature range which led to calculation of a Gibbs free energy, enthalpy and entropy of transfer for procaine hydrochloride. Successful application of this technique was confirmed using a second compound over a range of temperatures, namely caffeine. Overall, this work confirms that MLC can be used to determine precise and accurate partition coefficients that possibly more closely mimic biological membranes than traditional in vitro systems, namely octanol/water.",
keywords = "systems, model, penetration, Micelle, local-anesthetics, octanol-water, Procaine, MLC, sodium, hplc, performance liquid-chromatography, Partition coefficient, Caffeine",
author = "Waters, {L J} and Barbara Kasprzyk-Hordern",
year = "2010",
doi = "10.1007/s10973-010-0994-3",
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T1 - Micellar chromatographic determination of partition coefficients and associated thermodynamic data for pharmaceutical compounds

AU - Waters, L J

AU - Kasprzyk-Hordern, Barbara

PY - 2010

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N2 - Micelle/water partition coefficients were obtained for procaine hydrochloride using micellar liquid chromatography (MLC) to illustrate the potential application of this technique to compounds of pharmaceutical interest. Experiments were conducted over a temperature range which led to calculation of a Gibbs free energy, enthalpy and entropy of transfer for procaine hydrochloride. Successful application of this technique was confirmed using a second compound over a range of temperatures, namely caffeine. Overall, this work confirms that MLC can be used to determine precise and accurate partition coefficients that possibly more closely mimic biological membranes than traditional in vitro systems, namely octanol/water.

AB - Micelle/water partition coefficients were obtained for procaine hydrochloride using micellar liquid chromatography (MLC) to illustrate the potential application of this technique to compounds of pharmaceutical interest. Experiments were conducted over a temperature range which led to calculation of a Gibbs free energy, enthalpy and entropy of transfer for procaine hydrochloride. Successful application of this technique was confirmed using a second compound over a range of temperatures, namely caffeine. Overall, this work confirms that MLC can be used to determine precise and accurate partition coefficients that possibly more closely mimic biological membranes than traditional in vitro systems, namely octanol/water.

KW - systems

KW - model

KW - penetration

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KW - local-anesthetics

KW - octanol-water

KW - Procaine

KW - MLC

KW - sodium

KW - hplc

KW - performance liquid-chromatography

KW - Partition coefficient

KW - Caffeine

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DO - 10.1007/s10973-010-0994-3

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VL - 102

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EP - 347

JO - Journal of Thermographic Analysis and Calorimetry

JF - Journal of Thermographic Analysis and Calorimetry

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