TY - JOUR
T1 - Methods matter
T2 - A primer on permanent and reversible interference techniques in animals for investigators of human neuropsychology
AU - Bell, Andrew Harrison
AU - Bultitude, Janet H
N1 - Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.
PY - 2018/7/1
Y1 - 2018/7/1
N2 - The study of patients with brain lesions has contributed greatly to our understanding of the biological bases of human cognition, but this approach also has several unavoidable limitations. Research that uses animal models complements and extends human neuropsychology by addressing many of these limitations. In this review, we provide an overview of permanent and reversible animal lesion techniques for researchers of human neuropsychology, with the aim of highlighting how these methods provide a valuable adjunct to behavioural, neuroimaging, physiological, and clinical investigations in humans. Research in animals has provided important lessons about how the limitations of one or more techniques, or differences in their mechanism of action, has impacted upon the understanding of brain organisation and function. These cautionary tales highlight the importance of striving for a thorough understanding of how any intereference technique works (whether in animal or human), and for how to best use animal research to clarify the precise mechanisms underlying temporary lesion methods in humans.
AB - The study of patients with brain lesions has contributed greatly to our understanding of the biological bases of human cognition, but this approach also has several unavoidable limitations. Research that uses animal models complements and extends human neuropsychology by addressing many of these limitations. In this review, we provide an overview of permanent and reversible animal lesion techniques for researchers of human neuropsychology, with the aim of highlighting how these methods provide a valuable adjunct to behavioural, neuroimaging, physiological, and clinical investigations in humans. Research in animals has provided important lessons about how the limitations of one or more techniques, or differences in their mechanism of action, has impacted upon the understanding of brain organisation and function. These cautionary tales highlight the importance of striving for a thorough understanding of how any intereference technique works (whether in animal or human), and for how to best use animal research to clarify the precise mechanisms underlying temporary lesion methods in humans.
KW - Journal Article
UR - https://doi.org/10.1016/j.neuropsychologia.2017.09.019
UR - https://doi.org/10.1016/j.neuropsychologia.2017.09.019
U2 - 10.1016/j.neuropsychologia.2017.09.019
DO - 10.1016/j.neuropsychologia.2017.09.019
M3 - Article
C2 - 28943365
SN - 0028-3932
VL - 115
SP - 211
EP - 219
JO - Neuropsychologia
JF - Neuropsychologia
ER -