Methods (AMACR).

Matthew Lloyd (Inventor), Timothy Woodman (Inventor), Maksims Jevglevskis (Inventor), Michael Threadgill (Inventor), Guat Ling Lee (Inventor)

Research output: Patent

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Abstract

A method of measuring α-methylacyl-CoA racemase (AMACR) activity in a sample is described comprising the steps of: (i) providing a sample; (ii) contacting said sample with a substrate compound that undergoes elimination of hydrogen and a leaving group catalysed by said AMACR to produce a product compound having an additional carbon-carbon double bond; and (iii) measuring the amount of said leaving group and/or of said product compound and/or of unreacted substrate compound. Also provided are methods of diagnosis and medical imaging, in particular for use in diagnosing prostate cancer. Also provided are substrate compounds of Formula 1 for use in the methods described herein.
Original languageEnglish
Patent numberWO 2015 /114383 A1 EP3102694 (A1) US2017176436 (A1)
Priority date3/02/14
Filing date2/02/15
Publication statusPublished - 6 Aug 2015

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Substrates
Carbon
Medical imaging
Hydrogen
alpha-methylacyl-CoA racemase

Keywords

  • AMACR

Cite this

Lloyd, M., Woodman, T., Jevglevskis, M., Threadgill, M., & Lee, G. L. (2015). Methods (AMACR). (Patent No. WO 2015 /114383 A1 EP3102694 (A1) US2017176436 (A1) ).

Methods (AMACR). / Lloyd, Matthew (Inventor); Woodman, Timothy (Inventor); Jevglevskis, Maksims (Inventor); Threadgill, Michael (Inventor); Lee, Guat Ling (Inventor).

Patent No.: WO 2015 /114383 A1 EP3102694 (A1) US2017176436 (A1) . Feb 02, 2015.

Research output: Patent

Lloyd, M, Woodman, T, Jevglevskis, M, Threadgill, M & Lee, GL Feb. 02 2015, Methods (AMACR)., Patent No. WO 2015 /114383 A1 EP3102694 (A1) US2017176436 (A1) .
Lloyd M, Woodman T, Jevglevskis M, Threadgill M, Lee GL, inventors. Methods (AMACR). WO 2015 /114383 A1 EP3102694 (A1) US2017176436 (A1) . 2015 Aug 6.
Lloyd, Matthew (Inventor) ; Woodman, Timothy (Inventor) ; Jevglevskis, Maksims (Inventor) ; Threadgill, Michael (Inventor) ; Lee, Guat Ling (Inventor). / Methods (AMACR). Patent No.: WO 2015 /114383 A1 EP3102694 (A1) US2017176436 (A1) . Feb 02, 2015.
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