Methods (AMACR).

Matthew Lloyd (Inventor), Timothy Woodman (Inventor), Maksims Jevglevskis (Inventor), Michael Threadgill (Inventor), Guat Ling Lee (Inventor)

Research output: Patent

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Abstract

A method of measuring α-methylacyl-CoA racemase (AMACR) activity in a sample is described comprising the steps of: (i) providing a sample; (ii) contacting said sample with a substrate compound that undergoes elimination of hydrogen and a leaving group catalysed by said AMACR to produce a product compound having an additional carbon-carbon double bond; and (iii) measuring the amount of said leaving group and/or of said product compound and/or of unreacted substrate compound. Also provided are methods of diagnosis and medical imaging, in particular for use in diagnosing prostate cancer. Also provided are substrate compounds of Formula 1 for use in the methods described herein.
Original languageEnglish
Patent numberWO 2015 /114383 A1 EP3102694 (A1) US2017176436 (A1)
IPCC12Q1/533; G01N33/574;
Priority date3/02/14
Filing date2/02/15
Publication statusPublished - 6 Aug 2015

Keywords

  • AMACR

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