Methods (AMACR).

Matthew Lloyd; Timothy Woodman; Maksims Jevglevskis; Michael Threadgill; Guat Ling Lee

Methods (AMACR).

Matthew Lloyd (Inventor), Timothy Woodman (Inventor), Maksims Jevglevskis (Inventor), Michael Threadgill (Inventor), Guat Ling Lee (Inventor)

Research output: Patent

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Abstract

A method of measuring α-methylacyl-CoA racemase (AMACR) activity in a sample is described comprising the steps of: (i) providing a sample; (ii) contacting said sample with a substrate compound that undergoes elimination of hydrogen and a leaving group catalysed by said AMACR to produce a product compound having an additional carbon-carbon double bond; and (iii) measuring the amount of said leaving group and/or of said product compound and/or of unreacted substrate compound. Also provided are methods of diagnosis and medical imaging, in particular for use in diagnosing prostate cancer. Also provided are substrate compounds of Formula 1 for use in the methods described herein.

Original language	English
Patent number	WO2015114383A1
IPC	C12Q1/533,G01N33/574
Priority date	3/02/14
Filing date	2/02/15
Publication status	Published - 6 Aug 2015

Keywords

AMACR

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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WO2015114383Submitted manuscript, 2.44 MB

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abstract = "A method of measuring α-methylacyl-CoA racemase (AMACR) activity in a sample is described comprising the steps of: (i) providing a sample; (ii) contacting said sample with a substrate compound that undergoes elimination of hydrogen and a leaving group catalysed by said AMACR to produce a product compound having an additional carbon-carbon double bond; and (iii) measuring the amount of said leaving group and/or of said product compound and/or of unreacted substrate compound. Also provided are methods of diagnosis and medical imaging, in particular for use in diagnosing prostate cancer. Also provided are substrate compounds of Formula 1 for use in the methods described herein.",

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AU - Lloyd, Matthew

AU - Woodman, Timothy

AU - Jevglevskis, Maksims

AU - Threadgill, Michael

AU - Lee, Guat Ling

PY - 2015/8/6

Y1 - 2015/8/6

N2 - A method of measuring α-methylacyl-CoA racemase (AMACR) activity in a sample is described comprising the steps of: (i) providing a sample; (ii) contacting said sample with a substrate compound that undergoes elimination of hydrogen and a leaving group catalysed by said AMACR to produce a product compound having an additional carbon-carbon double bond; and (iii) measuring the amount of said leaving group and/or of said product compound and/or of unreacted substrate compound. Also provided are methods of diagnosis and medical imaging, in particular for use in diagnosing prostate cancer. Also provided are substrate compounds of Formula 1 for use in the methods described herein.

AB - A method of measuring α-methylacyl-CoA racemase (AMACR) activity in a sample is described comprising the steps of: (i) providing a sample; (ii) contacting said sample with a substrate compound that undergoes elimination of hydrogen and a leaving group catalysed by said AMACR to produce a product compound having an additional carbon-carbon double bond; and (iii) measuring the amount of said leaving group and/or of said product compound and/or of unreacted substrate compound. Also provided are methods of diagnosis and medical imaging, in particular for use in diagnosing prostate cancer. Also provided are substrate compounds of Formula 1 for use in the methods described herein.

KW - AMACR

UR - https://worldwide.espacenet.com/patent/search/family/050344307/publication/WO2015114383A1?q=pn%3DUS2017176436A1

M3 - Patent

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Y2 - 2015/02/02

ER -

Methods (AMACR).

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Avance III 500 MHz Nuclear Magnetic Resonance (NMR) Spectrometer (9West)

MC2-Mass Spectrometry (MS)

MC2- Nuclear Magnetic Resonance (NMR)

Cite this

Methods (AMACR).

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Equipment

Avance III 500 MHz Nuclear Magnetic Resonance (NMR) Spectrometer (9West)

MC2-Mass Spectrometry (MS)

MC2- Nuclear Magnetic Resonance (NMR)

Cite this