Projects per year
Abstract
A method of measuring α-methylacyl-CoA racemase (AMACR) activity in a sample is described comprising the steps of: (i) providing a sample; (ii) contacting said sample with a substrate compound that undergoes elimination of hydrogen and a leaving group catalysed by said AMACR to produce a product compound having an additional carbon- carbon double bond; and (iii) measuring the amount of said leaving group and/or of said product compound and/or of unreacted substrate compound. Also provided are methods of diagnosis and medical imaging, in particular for use in diagnosing prostate cancer. Also provided are substrate compounds of Formula 1 for use in the methods described herein.
Original language | English |
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Patent number | US20170176436 A1 |
Priority date | 3/02/14 |
Publication status | Published - 22 Jun 2017 |
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Projects
- 3 Finished
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Synthesis and evaluation of substrate-product hybrids as α-methylacyl-CoA racemase (AMACR) inhibitors
Lloyd, M., Woodman, T. & Jevglevskis, M.
1/08/16 → 19/09/16
Project: UK charity
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AMACR Targeted Drugs for Treating Advance Prostate Cancer
Lloyd, M., James, T., Jevglevskis, M., Nathubhai, A., Threadgill, M. & Woodman, T.
1/02/15 → 30/07/18
Project: UK charity
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