Methods (amacr)

Matthew Lloyd (Inventor), Maksims Jevglevskis (Inventor), Guat Ling Lee (Inventor), Timothy Woodman (Inventor), Michael Threadgill (Inventor)

Research output: Patent

Abstract

A method of measuring α-methylacyl-CoA racemase (AMACR) activity in a sample is described comprising the steps of: (i) providing a sample; (ii) contacting said sample with a substrate compound that undergoes elimination of hydrogen and a leaving group catalysed by said AMACR to produce a product compound having an additional carbon- carbon double bond; and (iii) measuring the amount of said leaving group and/or of said product compound and/or of unreacted substrate compound. Also provided are methods of diagnosis and medical imaging, in particular for use in diagnosing prostate cancer. Also provided are substrate compounds of Formula 1 for use in the methods described herein.
Original languageEnglish
Patent numberUS20170176436 A1
Priority date3/02/14
Publication statusPublished - 22 Jun 2017

Cite this

Lloyd, M., Jevglevskis, M., Lee, G. L., Woodman, T., & Threadgill, M. (2017). Methods (amacr). (Patent No. US20170176436 A1).

Methods (amacr). / Lloyd, Matthew (Inventor); Jevglevskis, Maksims (Inventor); Lee, Guat Ling (Inventor); Woodman, Timothy (Inventor); Threadgill, Michael (Inventor).

Patent No.: US20170176436 A1.

Research output: Patent

Lloyd, M, Jevglevskis, M, Lee, GL, Woodman, T & Threadgill, M 2017, Methods (amacr), Patent No. US20170176436 A1.
Lloyd M, Jevglevskis M, Lee GL, Woodman T, Threadgill M, inventors. Methods (amacr). US20170176436 A1. 2017 Jun 22.
Lloyd, Matthew (Inventor) ; Jevglevskis, Maksims (Inventor) ; Lee, Guat Ling (Inventor) ; Woodman, Timothy (Inventor) ; Threadgill, Michael (Inventor). / Methods (amacr). Patent No.: US20170176436 A1.
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