Methods (amacr)

Matthew Lloyd; Maksims Jevglevskis; Guat Ling Lee; Timothy Woodman; Michael Threadgill

Methods (amacr)

Matthew Lloyd (Inventor), Maksims Jevglevskis (Inventor), Guat Ling Lee (Inventor), Timothy Woodman (Inventor), Michael Threadgill (Inventor)

Department of Pharmacy & Pharmacology

Research output: Patent

Abstract

A method of measuring α-methylacyl-CoA racemase (AMACR) activity in a sample is described comprising the steps of: (i) providing a sample; (ii) contacting said sample with a substrate compound that undergoes elimination of hydrogen and a leaving group catalysed by said AMACR to produce a product compound having an additional carbon- carbon double bond; and (iii) measuring the amount of said leaving group and/or of said product compound and/or of unreacted substrate compound. Also provided are methods of diagnosis and medical imaging, in particular for use in diagnosing prostate cancer. Also provided are substrate compounds of Formula 1 for use in the methods described herein.

Original language	English
Patent number	US20170176436 A1
Priority date	3/02/14
Publication status	Published - 22 Jun 2017

Access to Document

Espacenet link

Projects

3 Finished

Synthesis and evaluation of substrate-product hybrids as α-methylacyl-CoA racemase (AMACR) inhibitors

Lloyd, M., Woodman, T. & Jevglevskis, M.

1/08/16 → 19/09/16

Project: UK charity

AMACR Targeted Drugs for Treating Advance Prostate Cancer

Lloyd, M., James, T., Jevglevskis, M., Nathubhai, A., Threadgill, M. & Woodman, T.

Prostate Cancer UK

1/02/15 → 30/07/18

Project: UK charity

Targeting AMACR to Treat Castrate Resistant Prostate Cancer

Lloyd, M. & Woodman, T.

Prostate Cancer UK

5/10/11 → 31/01/15

Project: UK charity

Cite this

Lloyd, M., Jevglevskis, M., Lee, G. L., Woodman, T., & Threadgill, M. (2017). Methods (amacr). (Patent No. US20170176436 A1).

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AU - Jevglevskis, Maksims

AU - Lee, Guat Ling

AU - Woodman, Timothy

AU - Threadgill, Michael

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AB - A method of measuring α-methylacyl-CoA racemase (AMACR) activity in a sample is described comprising the steps of: (i) providing a sample; (ii) contacting said sample with a substrate compound that undergoes elimination of hydrogen and a leaving group catalysed by said AMACR to produce a product compound having an additional carbon- carbon double bond; and (iii) measuring the amount of said leaving group and/or of said product compound and/or of unreacted substrate compound. Also provided are methods of diagnosis and medical imaging, in particular for use in diagnosing prostate cancer. Also provided are substrate compounds of Formula 1 for use in the methods described herein.

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