Methods (amacr)

Matthew Lloyd; Maksims Jevglevskis; Guat Ling Lee; Timothy Woodman; Michael Threadgill

Methods (amacr)

Matthew Lloyd (Inventor), Maksims Jevglevskis (Inventor), Guat Ling Lee (Inventor), Timothy Woodman (Inventor), Michael Threadgill (Inventor)

Department of Pharmacy & Pharmacology

Research output: Patent

Abstract

A method of measuring α-methylacyl-CoA racemase (AMACR) activity in a sample is described comprising the steps of: (i) providing a sample; (ii) contacting said sample with a substrate compound that undergoes elimination of hydrogen and a leaving group catalysed by said AMACR to produce a product compound having an additional carbon- carbon double bond; and (iii) measuring the amount of said leaving group and/or of said product compound and/or of unreacted substrate compound. Also provided are methods of diagnosis and medical imaging, in particular for use in diagnosing prostate cancer. Also provided are substrate compounds of Formula 1 for use in the methods described herein.

Original language	English
Patent number	US20170176436 A1
Priority date	3/02/14
Publication status	Published - 22 Jun 2017

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3 Finished

Synthesis and evaluation of substrate-product hybrids as α-methylacyl-CoA racemase (AMACR) inhibitors
Lloyd, M., Woodman, T. & Jevglevskis, M.
1/08/16 → 19/09/16
Project: UK charity
AMACR Targeted Drugs for Treating Advance Prostate Cancer
Lloyd, M., James, T., Jevglevskis, M., Nathubhai, A., Threadgill, M. & Woodman, T.
Prostate Cancer UK
1/02/15 → 30/07/18
Project: UK charity
Targeting AMACR to Treat Castrate Resistant Prostate Cancer
Lloyd, M. & Woodman, T.
Prostate Cancer UK
5/10/11 → 31/01/15
Project: UK charity

Avance III 500 NMR Spectrometer 500 MHz Nuclear Magnetic Resonance instrument (NMR) (9West)
Tim Woodman
Material and Chemical Characterisation (MC2)
Facility/equipment: Equipment

Cite this

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title = "Methods (amacr)",

abstract = "A method of measuring α-methylacyl-CoA racemase (AMACR) activity in a sample is described comprising the steps of: (i) providing a sample; (ii) contacting said sample with a substrate compound that undergoes elimination of hydrogen and a leaving group catalysed by said AMACR to produce a product compound having an additional carbon- carbon double bond; and (iii) measuring the amount of said leaving group and/or of said product compound and/or of unreacted substrate compound. Also provided are methods of diagnosis and medical imaging, in particular for use in diagnosing prostate cancer. Also provided are substrate compounds of Formula 1 for use in the methods described herein.",

author = "Matthew Lloyd and Maksims Jevglevskis and Lee, {Guat Ling} and Timothy Woodman and Michael Threadgill",

year = "2017",

month = jun,

day = "22",

language = "English",

type = "Patent",

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T1 - Methods (amacr)

AU - Lloyd, Matthew

AU - Jevglevskis, Maksims

AU - Lee, Guat Ling

AU - Woodman, Timothy

AU - Threadgill, Michael

PY - 2017/6/22

Y1 - 2017/6/22

N2 - A method of measuring α-methylacyl-CoA racemase (AMACR) activity in a sample is described comprising the steps of: (i) providing a sample; (ii) contacting said sample with a substrate compound that undergoes elimination of hydrogen and a leaving group catalysed by said AMACR to produce a product compound having an additional carbon- carbon double bond; and (iii) measuring the amount of said leaving group and/or of said product compound and/or of unreacted substrate compound. Also provided are methods of diagnosis and medical imaging, in particular for use in diagnosing prostate cancer. Also provided are substrate compounds of Formula 1 for use in the methods described herein.

AB - A method of measuring α-methylacyl-CoA racemase (AMACR) activity in a sample is described comprising the steps of: (i) providing a sample; (ii) contacting said sample with a substrate compound that undergoes elimination of hydrogen and a leaving group catalysed by said AMACR to produce a product compound having an additional carbon- carbon double bond; and (iii) measuring the amount of said leaving group and/or of said product compound and/or of unreacted substrate compound. Also provided are methods of diagnosis and medical imaging, in particular for use in diagnosing prostate cancer. Also provided are substrate compounds of Formula 1 for use in the methods described herein.

UR - https://worldwide.espacenet.com/publicationDetails/inpadocPatentFamily?CC=WO&NR=2015114383A1&KC=A1&FT=D&ND=3&date=20150806&DB=&locale=en_EP

M3 - Patent

M1 - US20170176436 A1

ER -

Methods (amacr)

Abstract

Access to Document

Synthesis and evaluation of substrate-product hybrids as α-methylacyl-CoA racemase (AMACR) inhibitors

AMACR Targeted Drugs for Treating Advance Prostate Cancer

Targeting AMACR to Treat Castrate Resistant Prostate Cancer

Avance III 500 NMR Spectrometer 500 MHz Nuclear Magnetic Resonance instrument (NMR) (9West)

Cite this