Projects per year
Abstract
A method of measuring α-methylacyl-CoA racemase (AMACR) activity in a sample is described comprising the steps of: (i) providing a sample; (ii) contacting said sample with a substrate compound that undergoes elimination of hydrogen and a leaving group catalysed by said AMACR to produce a product compound having an additional carbon- carbon double bond; and (iii) measuring the amount of said leaving group and/or of said product compound and/or of unreacted substrate compound. Also provided are methods of diagnosis and medical imaging, in particular for use in diagnosing prostate cancer. Also provided are substrate compounds of Formula 1 for use in the methods described herein.
Original language | English |
---|---|
Patent number | US20170176436 A1 |
Priority date | 3/02/14 |
Publication status | Published - 22 Jun 2017 |
Fingerprint
Dive into the research topics of 'Methods (amacr)'. Together they form a unique fingerprint.Projects
- 2 Finished
-
AMACR Targeted Drugs for Treating Advance Prostate Cancer
Lloyd, M., James, T., Jevglevskis, M., Nathubhai, A., Threadgill, M. & Woodman, T.
1/02/15 → 30/07/18
Project: UK charity
-
Equipment
-
Avance III 500 MHz Nuclear Magnetic Resonance (NMR) Spectrometer (9West)
Material and Chemical Characterisation (MC2)Facility/equipment: Equipment