Projects per year
A method of measuring α-methylacyl-CoA racemase (AMACR) activity in a sample is described comprising the steps of: (i) providing a sample; (ii) contacting said sample with a substrate compound that undergoes elimination of hydrogen and a leaving group catalysed by said AMACR to produce a product compound having an additional carbon- carbon double bond; and (iii) measuring the amount of said leaving group and/or of said product compound and/or of unreacted substrate compound. Also provided are methods of diagnosis and medical imaging, in particular for use in diagnosing prostate cancer. Also provided are substrate compounds of Formula 1 for use in the methods described herein.
|Patent number||US20170176436 A1|
|Publication status||Published - 22 Jun 2017|
Synthesis and evaluation of substrate-product hybrids as α-methylacyl-CoA racemase (AMACR) inhibitors
1/08/16 → 19/09/16
Project: UK charity