Abstract
| Language | English |
|---|---|
| Patent number | US20170176436 A1 |
| Priority date | 3/02/14 |
| Status | Published - 22 Jun 2017 |
Cite this
Methods (amacr). / Lloyd, Matthew (Inventor); Jevglevskis, Maksims (Inventor); Lee, Guat Ling (Inventor); Woodman, Timothy (Inventor); Threadgill, Michael (Inventor).
Patent No.: US20170176436 A1.Research output: Patent
}
TY - PAT
T1 - Methods (amacr)
AU - Lloyd, Matthew
AU - Jevglevskis, Maksims
AU - Lee, Guat Ling
AU - Woodman, Timothy
AU - Threadgill, Michael
PY - 2017/6/22
Y1 - 2017/6/22
N2 - A method of measuring α-methylacyl-CoA racemase (AMACR) activity in a sample is described comprising the steps of: (i) providing a sample; (ii) contacting said sample with a substrate compound that undergoes elimination of hydrogen and a leaving group catalysed by said AMACR to produce a product compound having an additional carbon- carbon double bond; and (iii) measuring the amount of said leaving group and/or of said product compound and/or of unreacted substrate compound. Also provided are methods of diagnosis and medical imaging, in particular for use in diagnosing prostate cancer. Also provided are substrate compounds of Formula 1 for use in the methods described herein.
AB - A method of measuring α-methylacyl-CoA racemase (AMACR) activity in a sample is described comprising the steps of: (i) providing a sample; (ii) contacting said sample with a substrate compound that undergoes elimination of hydrogen and a leaving group catalysed by said AMACR to produce a product compound having an additional carbon- carbon double bond; and (iii) measuring the amount of said leaving group and/or of said product compound and/or of unreacted substrate compound. Also provided are methods of diagnosis and medical imaging, in particular for use in diagnosing prostate cancer. Also provided are substrate compounds of Formula 1 for use in the methods described herein.
UR - https://worldwide.espacenet.com/publicationDetails/inpadocPatentFamily?CC=WO&NR=2015114383A1&KC=A1&FT=D&ND=3&date=20150806&DB=&locale=en_EP
M3 - Patent
M1 - US20170176436 A1
ER -