Methods (AMACR)

Matthew Lloyd (Inventor), Maksims Jevglevskis (Inventor), Guat Ling Lee (Inventor), Timothy Woodman (Inventor), Michael Threadgill (Inventor)

Research output: Patent

Abstract

A method of measuring α-methylacyl-CoA racemase (AMACR) activity in a sample is described comprising the steps of: (i) providing a sample; (ii) contacting said sample with a substrate compound that undergoes elimination of hydrogen and a leaving group catalysed by said AMACR to produce a product compound having an additional carbon- carbon double bond; and (iii) measuring the amount of said leaving group and/or of said product compound and/or of unreacted substrate compound. Also provided are methods of diagnosis and medical imaging, in particular for use in diagnosing prostate cancer. Also provided are substrate compounds of Formula 1 for use in the methods described herein.
Original languageEnglish
Patent numberEP3102694 A1
Priority date3/02/14
Publication statusPublished - 14 Dec 2016

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Cite this

Lloyd, M., Jevglevskis, M., Lee, G. L., Woodman, T., & Threadgill, M. (2016). Methods (AMACR). (Patent No. EP3102694 A1).