Metaplasia and transdifferentiation: from pure biology to the clinic

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160 Citations (Scopus)

Abstract

Transformations from one tissue type to another make up a well established set of phenomena that can be explained by the principles of developmental biology. Although these phenomena might be rare in nature, we can now imagine the possibility of deliberately reprogramming cells from one tissue type to another by manipulating the expression of transcription factors. This approach could generate new therapies for many human diseases.
Original languageEnglish
Pages (from-to)369-378
Number of pages10
JournalNature Reviews Molecular Cell Biology
Volume8
Issue number5
DOIs
Publication statusPublished - 2007

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