Metaplasia and transdifferentiation: from pure biology to the clinic

J M W Slack

doi:10.1038/nrm2146

Metaplasia and transdifferentiation: from pure biology to the clinic

J M W Slack

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

191 Citations (SciVal)

Abstract

Transformations from one tissue type to another make up a well established set of phenomena that can be explained by the principles of developmental biology. Although these phenomena might be rare in nature, we can now imagine the possibility of deliberately reprogramming cells from one tissue type to another by manipulating the expression of transcription factors. This approach could generate new therapies for many human diseases.

Original language	English
Pages (from-to)	369-378
Number of pages	10
Journal	Nature Reviews Molecular Cell Biology
Volume	8
Issue number	5
DOIs	https://doi.org/10.1038/nrm2146
Publication status	Published - 2007

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10.1038/nrm2146

BETA CELLS IN THE LIVER
Tosh, D. & Slack, J.
MRC
1/01/06 → 31/12/08
Project: Research council
COOPERATIVE GROUP IN ORGANOGENESIS, GROWTH AND REGENERATION
Ward, A., Holman, G., Hurst, L., Kelsh, R., Slack, J. & Tosh, D.
MRC
21/06/04 → 20/06/09
Project: Research council

Cite this

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abstract = "Transformations from one tissue type to another make up a well established set of phenomena that can be explained by the principles of developmental biology. Although these phenomena might be rare in nature, we can now imagine the possibility of deliberately reprogramming cells from one tissue type to another by manipulating the expression of transcription factors. This approach could generate new therapies for many human diseases.",

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Metaplasia and transdifferentiation: from pure biology to the clinic

Abstract

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Projects

BETA CELLS IN THE LIVER

COOPERATIVE GROUP IN ORGANOGENESIS, GROWTH AND REGENERATION

Cite this