Metaplasia and somatic cell reprogramming

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23 Citations (Scopus)

Abstract

The nature and occurrence of metaplasia is briefly reviewed. A theory of how metaplasia is initiated is presented, depending on the idea that it represents an alteration in the combination of developmental transcription factors that are expressed. Two examples of experimental metaplasia, provoked by over-expression of specific transcription factors, are presented: the transformation of B lymphocytes to macrophages, and of pancreatic exocrine cells to hepatocytes. The formation of induced pluripotential stem cells (iPS cells) is considered an example of the same process, in which the destination state is the embryonic stem cell. It is noted that iPS cell production is a stochastic process, depending on selection to obtain the desired cell type. It is proposed that analogous technology, using the appropriate transcription factors, could be used to bring about transformation to cell types other than embryonic stem cells.
Original languageEnglish
Pages (from-to)161-168
Number of pages8
JournalThe Journal of Pathology
Volume217
Issue number2
Early online date11 Sep 2008
DOIs
Publication statusPublished - 2009

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  • Projects

    BETA CELLS IN THE LIVER

    Tosh, D. & Slack, J.

    Medical Research Council

    1/01/0631/12/08

    Project: Research council

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