TY - JOUR
T1 - Metals ions and neurodegeneration
AU - Molina-Holgado, Francisco
AU - Hider, Robert C
AU - Gaeta, Alessandra
AU - Williams, Robert
AU - Francis, Paul
PY - 2007
Y1 - 2007
N2 - Neurodegenerative disorders include a variety of pathological conditions, which share similar critical metabolic processes such as protein aggregation and oxidative stress, both of which are associated with the involvement of metal ions. In this review Alzheimer's disease and Parkinson's disease are mainly discussed, with the aim of identifying common trends underlying these neurological conditions. Chelation therapy could be a valuable therapeutic approach, since metals are considered to be a pharmacological target for the rationale design of new therapeutic agents directed towards the treatment of neurodegeneration.
AB - Neurodegenerative disorders include a variety of pathological conditions, which share similar critical metabolic processes such as protein aggregation and oxidative stress, both of which are associated with the involvement of metal ions. In this review Alzheimer's disease and Parkinson's disease are mainly discussed, with the aim of identifying common trends underlying these neurological conditions. Chelation therapy could be a valuable therapeutic approach, since metals are considered to be a pharmacological target for the rationale design of new therapeutic agents directed towards the treatment of neurodegeneration.
UR - http://dx.doi.org/10.1007/s10534-006-9033-z
U2 - 10.1007/s10534-006-9033-z
DO - 10.1007/s10534-006-9033-z
M3 - Article
C2 - 17294125
SN - 0966-0844
VL - 20
SP - 639
EP - 654
JO - Biometals
JF - Biometals
IS - 3-4
ER -