Metals ions and neurodegeneration

Francisco Molina-Holgado, Robert C Hider, Alessandra Gaeta, Robert Williams, Paul Francis

Research output: Contribution to journalArticlepeer-review

175 Citations (SciVal)


Neurodegenerative disorders include a variety of pathological conditions, which share similar critical metabolic processes such as protein aggregation and oxidative stress, both of which are associated with the involvement of metal ions. In this review Alzheimer's disease and Parkinson's disease are mainly discussed, with the aim of identifying common trends underlying these neurological conditions. Chelation therapy could be a valuable therapeutic approach, since metals are considered to be a pharmacological target for the rationale design of new therapeutic agents directed towards the treatment of neurodegeneration.
Original languageEnglish
Pages (from-to)639-54
Number of pages16
Issue number3-4
Publication statusPublished - 2007


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