Metals and the skin

Jurij J. Hostýnek, Robert S. Hinz, Cynthia R. Lorence, Matthew Price, Richard H. Guy

Research output: Contribution to journalArticlepeer-review


Certain metals, and many metal-based compounds, are inherently toxic, and their presence in occupational and environmental settings raises appropriate questions concerning human exposure. Contact of these materials with the skin represents an important route of exposure, which is not well characterized. The purpose of this review, therefore, is to assemble the available, useful information pertinent to risk assessment following dermal contact. Specifically, we summarize here: (1) data relevant to the qualitative and (where possible) quantitative evaluation of metal compound permeation through the skin; (2) the role of each metal in metabolism, particularly with respect to the skin, and the potentially toxic effects that may result from dermal contact; and (3) the immunological characteristics (including allergenicity) of the metals and their derivatives. In total, information on 31 metals has been reviewed. It is clear that many diverse factors determine the ability of metal-based species to permeate biological membranes, not all of which have been fully defined. Therefore, considerably more experimentation, targeted at the development of high-quality transport data, will be required before the specification of practically useful structure-activity relationships are possible.

Original languageEnglish
Pages (from-to)171-235
Number of pages65
JournalCritical Reviews in Toxicology
Issue number2
Publication statusPublished - 31 Dec 1993

Bibliographical note

Funding Information:
Financial support was provided by a cooperative agreement (CR-8 16785) with the U.S. Environmental Protection Agency. We are indebted to Lauren Araiza, K. Hoang, and Dr. Christopher Cullander for their invaluable inputs and assistance with this work; and to Dr. Mal-gorzata Sznitowska and Swiatoslav Bozhenko for interpretation of Russian manuscripts.


  • Absorption
  • Allergy
  • Contact dermatitis
  • Immunology
  • Metals
  • Permeability
  • Skin
  • Toxicity

ASJC Scopus subject areas

  • Toxicology


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