Abstract
Phototherapy is a form of light-mediated therapy, which includes photodynamic therapy (PDT) photothermal therapy (PTT), and the recently emerging photoimmunotherapy (PIT). PTT, PDT, PIT and their combinations with conventional chemotherapeutics have been used extensively to treat cancer due to their outstanding therapeutic efficacy, are non-invasive, mitigate side effects, and display spatial selectivity for a target organ. In addition to the many anticancer phototherapeutic agents developed, metal-organic frameworks (MOFs) are a new generation of promising light-responsive materials owing to their readily tunable chemical structures through simple coordination chemistry as well as their morphological diversity. When properly designed, MOFs can also serve as photodynamic and/or photothermal agents themselves whilst being a carrier to deliver chemo- and macromolecular therapeutic agents owing to their highly tunable porosity. This review highlights recent research progresses made in the development of MOFs-based materials for phototherapy and synergistic phototherapy, as well as discussing any remaining challenges.
| Original language | English |
|---|---|
| Article number | 216381 |
| Journal | Coordination Chemistry Reviews |
| Volume | 526 |
| Early online date | 10 Dec 2024 |
| DOIs | |
| Publication status | E-pub ahead of print - 10 Dec 2024 |
Data Availability Statement
No data was used for the research described in the article.Funding
The authors thank the Natural National Science Foundation of China (NSFC) (Nos. 92253306, 82130099, 22108077 and 22477030), the Shanghai Municipal Science and Technology Major Project (No. 2018SHZDZX03), the International Cooperation Program of Shanghai Science and Technology (No.23490711600), the Fundamental Research Funds for the Central Universities (222201717003), the Programme of Introducing Talents of Discipline to Universities (B16017), the Open Funding Project of the State Key Laboratory of Bioreactor Engineering, State Key Laboratory of Drug Research (SKLDR-2023-KF-10) and Ministry of Education Key Laboratory on signaling Regulation and Targeting Therapy of Liver Cancer (Naval Medical University) (Grant. 2023-MEKLLC-MS/ZD-00*). J.Y. and K.T.N. thank for financial support. The Nano & Material Technology Development Program through the National Research Foundation of Korea (NRF) funded by Ministry of Science and ICT(RS-2024-00407093, K.T.N. and J.Y.). J.Y. thanks to the support by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MSIT) (No. 2022M3E5F3080873, J.Y.). T.D.J. wishes to thank the University of Bath and the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University (2020ZD01) for support. The Research Center of Analysis and Test of East China University of Science and Technology was gratefully acknowledged for assistance in analytical experiments.
Keywords
- Cancer
- Metal-organic frameworks (MOFs)
- Photodynamic therapy
- Phototherapy
- Photothermal therapy
- Synergistic therapy
ASJC Scopus subject areas
- General Chemistry
- Physical and Theoretical Chemistry
- Inorganic Chemistry
- Materials Chemistry
