Mechanistic investigation into antibacterial behaviour of suspensions of ZnO nanoparticles against E. coli

Lingling Zhang; Yunhong Jiang; Yulong Ding; Nikolaos Daskalakis; Lars Jeuken; Malcolm Povey; Alex J. O'Neill; David W York

doi:10.1007/s11051-009-9711-1

Mechanistic investigation into antibacterial behaviour of suspensions of ZnO nanoparticles against E. coli

Lingling Zhang, Yunhong Jiang, Yulong Ding, Nikolaos Daskalakis, Lars Jeuken, Malcolm Povey, Alex J. O'Neill, David W York

Department of Architecture & Civil Engineering

Procter & Gamble Innovation Centre

Research output: Contribution to journal › Article › peer-review

430 Citations (SciVal)

Abstract

Aqueous suspensions containing 4.45 ×10^-5 - 1.25 ×10^-3 M ZnO particles exhibit a strong antibacterial activity against E. coli under the dark conditions. The dominant mechanisms of such antibacterial behaviour are found to be either or both of chemical interactions between hydrogen peroxide and membrane proteins, and chemical interactionsbetween other unknown chemical species generated due to the presence of ZnO particles with the lipid bilayer. The effect of direct physical interactions between nanoparticles and biological cells are found to play a relatively small role under the con ditions of this study.

Original language	English
Pages (from-to)	1625-1636
Number of pages	12
Journal	Journal of Nanoparticle Research
Volume	12
Issue number	5
DOIs	https://doi.org/10.1007/s11051-009-9711-1
Publication status	Published - Jun 2010

Keywords

Antibacterial
E. coli
EHS
Lipid vesicles
Mechanism
Toxicity
ZnO nanoparticles

ASJC Scopus subject areas

Bioengineering
General Chemistry
Atomic and Molecular Physics, and Optics
Modelling and Simulation
General Materials Science
Condensed Matter Physics

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10.1007/s11051-009-9711-1

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abstract = "Aqueous suspensions containing 4.45 ×10-5 - 1.25 ×10-3 M ZnO particles exhibit a strong antibacterial activity against E. coli under the dark conditions. The dominant mechanisms of such antibacterial behaviour are found to be either or both of chemical interactions between hydrogen peroxide and membrane proteins, and chemical interactionsbetween other unknown chemical species generated due to the presence of ZnO particles with the lipid bilayer. The effect of direct physical interactions between nanoparticles and biological cells are found to play a relatively small role under the con ditions of this study.",

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author = "Lingling Zhang and Yunhong Jiang and Yulong Ding and Nikolaos Daskalakis and Lars Jeuken and Malcolm Povey and O'Neill, {Alex J.} and York, {David W}",

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AU - Zhang, Lingling

AU - Jiang, Yunhong

AU - Ding, Yulong

AU - Daskalakis, Nikolaos

AU - Jeuken, Lars

AU - Povey, Malcolm

AU - O'Neill, Alex J.

AU - York, David W

PY - 2010/6

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AB - Aqueous suspensions containing 4.45 ×10-5 - 1.25 ×10-3 M ZnO particles exhibit a strong antibacterial activity against E. coli under the dark conditions. The dominant mechanisms of such antibacterial behaviour are found to be either or both of chemical interactions between hydrogen peroxide and membrane proteins, and chemical interactionsbetween other unknown chemical species generated due to the presence of ZnO particles with the lipid bilayer. The effect of direct physical interactions between nanoparticles and biological cells are found to play a relatively small role under the con ditions of this study.

KW - Antibacterial

KW - E. coli

KW - EHS

KW - Lipid vesicles

KW - Mechanism

KW - Toxicity

KW - ZnO nanoparticles

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Mechanistic investigation into antibacterial behaviour of suspensions of ZnO nanoparticles against E. coli

Abstract

Keywords

ASJC Scopus subject areas

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