Mechanistic investigation into antibacterial behaviour of suspensions of ZnO nanoparticles against E. coli

Lingling Zhang, Yunhong Jiang, Yulong Ding, Nikolaos Daskalakis, Lars Jeuken, Malcolm Povey, Alex J. O'Neill, David W York

Research output: Contribution to journalArticle

272 Citations (Scopus)

Abstract

Aqueous suspensions containing 4.45 ×10-5 - 1.25 ×10-3 M ZnO particles exhibit a strong antibacterial activity against E. coli under the dark conditions. The dominant mechanisms of such antibacterial behaviour are found to be either or both of chemical interactions between hydrogen peroxide and membrane proteins, and chemical interactionsbetween other unknown chemical species generated due to the presence of ZnO particles with the lipid bilayer. The effect of direct physical interactions between nanoparticles and biological cells are found to play a relatively small role under the con ditions of this study.

Original languageEnglish
Pages (from-to)1625-1636
Number of pages12
JournalJournal of Nanoparticle Research
Volume12
Issue number5
DOIs
Publication statusPublished - Jun 2010

Fingerprint

Escherichia coli
Escherichia Coli
Nanoparticles
Suspensions
nanoparticles
Lipid bilayers
hydrogen peroxide
Hydrogen peroxide
Hydrogen Peroxide
lipids
Lipid Bilayer
Membrane Proteins
Membrane Protein
interactions
membranes
proteins
Proteins
Membranes
Interaction
cells

Keywords

  • Antibacterial
  • E. coli
  • EHS
  • Lipid vesicles
  • Mechanism
  • Toxicity
  • ZnO nanoparticles

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Atomic and Molecular Physics, and Optics
  • Modelling and Simulation
  • Materials Science(all)
  • Condensed Matter Physics

Cite this

Mechanistic investigation into antibacterial behaviour of suspensions of ZnO nanoparticles against E. coli. / Zhang, Lingling; Jiang, Yunhong; Ding, Yulong; Daskalakis, Nikolaos; Jeuken, Lars; Povey, Malcolm; O'Neill, Alex J.; York, David W.

In: Journal of Nanoparticle Research, Vol. 12, No. 5, 06.2010, p. 1625-1636.

Research output: Contribution to journalArticle

Zhang, L, Jiang, Y, Ding, Y, Daskalakis, N, Jeuken, L, Povey, M, O'Neill, AJ & York, DW 2010, 'Mechanistic investigation into antibacterial behaviour of suspensions of ZnO nanoparticles against E. coli', Journal of Nanoparticle Research, vol. 12, no. 5, pp. 1625-1636. https://doi.org/10.1007/s11051-009-9711-1
Zhang, Lingling ; Jiang, Yunhong ; Ding, Yulong ; Daskalakis, Nikolaos ; Jeuken, Lars ; Povey, Malcolm ; O'Neill, Alex J. ; York, David W. / Mechanistic investigation into antibacterial behaviour of suspensions of ZnO nanoparticles against E. coli. In: Journal of Nanoparticle Research. 2010 ; Vol. 12, No. 5. pp. 1625-1636.
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