Mechanistic insights into a BINOL-derived phosphoric acid-catalyzed asymmetric Pictet-Spengler reaction

Chemistry

• Enantioselectivity 100%
• Phosphoric Acid 100%
• Pictet-Spengler Synthesis 100%
• Density Functional Theory 50%
• Indole 50%
• Diastereoselectivity 50%
• Acetic Acid 50%
• Stereoselectivity 50%
• Hydrogen Atom 50%
• Phosphate Group 50%
• 2-Naphthol 50%
• Tryptamine 50%
• Molecular Mechanics Calculation 50%
• Hydrogen Bond 50%
• Oxygen Atom 50%