Measurement properties of radiographic outcome measures in Psoriatic Arthritis: A systematic review from the GRAPPA-OMERACT initiative

Anna Antony; Richard Holland; Maria Antonietta D'Agostino; Walter P. Maksymowych; Heidi Bertheussen; Lori Schick; Niti Goel; Alexis Ogdie; Ana Maria Orbai; P. Højgaard; Laura C. Coates; Vibeke Strand; Dafna D. Gladman; Robin Christensen; Ying Ying Leung; Philip Mease; William Tillett

doi:10.1016/j.semarthrit.2021.01.008

Measurement properties of radiographic outcome measures in Psoriatic Arthritis: A systematic review from the GRAPPA-OMERACT initiative

Anna Antony, Richard Holland, Maria Antonietta D'Agostino, Walter P. Maksymowych, Heidi Bertheussen, Lori Schick, Niti Goel, Alexis Ogdie, Ana Maria Orbai, P. Højgaard, Laura C. Coates, Vibeke Strand, Dafna D. Gladman, Robin Christensen, Ying Ying Leung, Philip Mease, William Tillett

Research output: Contribution to journal › Review article › peer-review

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Abstract

Background: Structural damage is as an important outcome in the Psoriatic Arthritis (PsA) Core Domain Set and its assessment is recommended at least once in the development of a new drug. Objectives: To conduct a systematic review (SR) to identify studies addressing the measurement properties of radiographic outcome instruments for structural damage in PsA and appraise the evidence through the Outcome Measures in Rheumatology (OMERACT) Filter 2.1 Framework Instrument Selection Algorithm (OFISA). Methods: A SR was conducted using search strategies in EMBASE and MEDLINE to identify full-text English studies which aimed to develop or assess the measurement properties of radiographic outcome instruments in PsA. Determination of eligibility and data extraction was performed independently by two reviewers with input from a third to achieve consensus. Two reviewers assessed the methodology and results of eligible studies and synthesized the evidence using OMERACT methodology. Results: Twelve articles evaluating radiographic instruments were included. The articles assessed nine peripheral (hands, wrists and/or feet) and six axial (spinal and/or sacroiliac joints) radiographic instruments. The peripheral radiographic instruments with some evidence for reliability, cross-sectional construct validity and longitudinal construct validity were the Ratingen and modified Sharp van der Heijde scores. No instruments had evidence for clinical trial discrimination or thresholds of meaning. There was limited evidence for the measurement properties of all identified axial instruments. Conclusion: There are significant knowledge gaps in the responsiveness of peripheral radiographic instruments. Axial radiographic instruments require further validation, and the need to generate novel instruments and utilise other imaging modalities should be considered.

Original language	English
Pages (from-to)	367-386
Number of pages	20
Journal	Seminars in Arthritis and Rheumatism
Volume	51
Issue number	2
Early online date	11 Feb 2021
DOIs	https://doi.org/10.1016/j.semarthrit.2021.01.008
Publication status	Published - 30 Apr 2021

Bibliographical note

Funding Information:
Professor R. Christensen acknowledges that the Parker Institute, Bispebjerg and Frederiksberg Hospital is supported by a core grant from the Oak Foundation ( OCAY-18-774-OFIL ). None of the funding sources had any influence on the study design, on data collection, data synthesis, data interpretation, writing the report, or the decision to submit the manuscript for publication.

Funding Information:
Dr Tillett reports grants from Abbvie, Celgene, Janssen, Lilly, and personal fees from Abbvie, Amgen, Celgene, Lilly, Janssen, MSD, Novartis, Pfizer and UCB, outside the submitted work.

Publisher Copyright:
© 2021 Elsevier Inc.

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

Funding

Professor R. Christensen acknowledges that the Parker Institute, Bispebjerg and Frederiksberg Hospital is supported by a core grant from the Oak Foundation ( OCAY-18-774-OFIL ). None of the funding sources had any influence on the study design, on data collection, data synthesis, data interpretation, writing the report, or the decision to submit the manuscript for publication. Dr Tillett reports grants from Abbvie, Celgene, Janssen, Lilly, and personal fees from Abbvie, Amgen, Celgene, Lilly, Janssen, MSD, Novartis, Pfizer and UCB, outside the submitted work.

Keywords

Imaging
Outcome instruments
Psoriatic Arthritis
Radiography

ASJC Scopus subject areas

Rheumatology
Anesthesiology and Pain Medicine

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10.1016/j.semarthrit.2021.01.008

Manuscript_Revision_7.11.2020.PDFAccepted author manuscript, 555 KBLicence: CC BY-NC-ND

Cite this

Antony, A., Holland, R., D'Agostino, M. A., Maksymowych, W. P., Bertheussen, H., Schick, L., Goel, N., Ogdie, A., Orbai, A. M., Højgaard, P., Coates, L. C., Strand, V., Gladman, D. D., Christensen, R., Leung, Y. Y., Mease, P., & Tillett, W. (2021). Measurement properties of radiographic outcome measures in Psoriatic Arthritis: A systematic review from the GRAPPA-OMERACT initiative. Seminars in Arthritis and Rheumatism, 51(2), 367-386. https://doi.org/10.1016/j.semarthrit.2021.01.008

Antony, A, Holland, R, D'Agostino, MA, Maksymowych, WP, Bertheussen, H, Schick, L, Goel, N, Ogdie, A, Orbai, AM, Højgaard, P, Coates, LC, Strand, V, Gladman, DD, Christensen, R, Leung, YY, Mease, P & Tillett, W 2021, 'Measurement properties of radiographic outcome measures in Psoriatic Arthritis: A systematic review from the GRAPPA-OMERACT initiative', Seminars in Arthritis and Rheumatism, vol. 51, no. 2, pp. 367-386. https://doi.org/10.1016/j.semarthrit.2021.01.008

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title = "Measurement properties of radiographic outcome measures in Psoriatic Arthritis: A systematic review from the GRAPPA-OMERACT initiative",

abstract = "Background: Structural damage is as an important outcome in the Psoriatic Arthritis (PsA) Core Domain Set and its assessment is recommended at least once in the development of a new drug. Objectives: To conduct a systematic review (SR) to identify studies addressing the measurement properties of radiographic outcome instruments for structural damage in PsA and appraise the evidence through the Outcome Measures in Rheumatology (OMERACT) Filter 2.1 Framework Instrument Selection Algorithm (OFISA). Methods: A SR was conducted using search strategies in EMBASE and MEDLINE to identify full-text English studies which aimed to develop or assess the measurement properties of radiographic outcome instruments in PsA. Determination of eligibility and data extraction was performed independently by two reviewers with input from a third to achieve consensus. Two reviewers assessed the methodology and results of eligible studies and synthesized the evidence using OMERACT methodology. Results: Twelve articles evaluating radiographic instruments were included. The articles assessed nine peripheral (hands, wrists and/or feet) and six axial (spinal and/or sacroiliac joints) radiographic instruments. The peripheral radiographic instruments with some evidence for reliability, cross-sectional construct validity and longitudinal construct validity were the Ratingen and modified Sharp van der Heijde scores. No instruments had evidence for clinical trial discrimination or thresholds of meaning. There was limited evidence for the measurement properties of all identified axial instruments. Conclusion: There are significant knowledge gaps in the responsiveness of peripheral radiographic instruments. Axial radiographic instruments require further validation, and the need to generate novel instruments and utilise other imaging modalities should be considered.",

keywords = "Imaging, Outcome instruments, Psoriatic Arthritis, Radiography",

author = "Anna Antony and Richard Holland and D'Agostino, {Maria Antonietta} and Maksymowych, {Walter P.} and Heidi Bertheussen and Lori Schick and Niti Goel and Alexis Ogdie and Orbai, {Ana Maria} and P. H{\o}jgaard and Coates, {Laura C.} and Vibeke Strand and Gladman, {Dafna D.} and Robin Christensen and Leung, {Ying Ying} and Philip Mease and William Tillett",

note = "Funding Information: Professor R. Christensen acknowledges that the Parker Institute, Bispebjerg and Frederiksberg Hospital is supported by a core grant from the Oak Foundation ( OCAY-18-774-OFIL ). None of the funding sources had any influence on the study design, on data collection, data synthesis, data interpretation, writing the report, or the decision to submit the manuscript for publication. Funding Information: Dr Tillett reports grants from Abbvie, Celgene, Janssen, Lilly, and personal fees from Abbvie, Amgen, Celgene, Lilly, Janssen, MSD, Novartis, Pfizer and UCB, outside the submitted work. Publisher Copyright: {\textcopyright} 2021 Elsevier Inc. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

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doi = "10.1016/j.semarthrit.2021.01.008",

language = "English",

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pages = "367--386",

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T1 - Measurement properties of radiographic outcome measures in Psoriatic Arthritis

T2 - A systematic review from the GRAPPA-OMERACT initiative

AU - Antony, Anna

AU - Holland, Richard

AU - D'Agostino, Maria Antonietta

AU - Maksymowych, Walter P.

AU - Bertheussen, Heidi

AU - Schick, Lori

AU - Goel, Niti

AU - Ogdie, Alexis

AU - Orbai, Ana Maria

AU - Højgaard, P.

AU - Coates, Laura C.

AU - Strand, Vibeke

AU - Gladman, Dafna D.

AU - Christensen, Robin

AU - Leung, Ying Ying

AU - Mease, Philip

AU - Tillett, William

N1 - Funding Information: Professor R. Christensen acknowledges that the Parker Institute, Bispebjerg and Frederiksberg Hospital is supported by a core grant from the Oak Foundation ( OCAY-18-774-OFIL ). None of the funding sources had any influence on the study design, on data collection, data synthesis, data interpretation, writing the report, or the decision to submit the manuscript for publication. Funding Information: Dr Tillett reports grants from Abbvie, Celgene, Janssen, Lilly, and personal fees from Abbvie, Amgen, Celgene, Lilly, Janssen, MSD, Novartis, Pfizer and UCB, outside the submitted work. Publisher Copyright: © 2021 Elsevier Inc. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/4/30

Y1 - 2021/4/30

N2 - Background: Structural damage is as an important outcome in the Psoriatic Arthritis (PsA) Core Domain Set and its assessment is recommended at least once in the development of a new drug. Objectives: To conduct a systematic review (SR) to identify studies addressing the measurement properties of radiographic outcome instruments for structural damage in PsA and appraise the evidence through the Outcome Measures in Rheumatology (OMERACT) Filter 2.1 Framework Instrument Selection Algorithm (OFISA). Methods: A SR was conducted using search strategies in EMBASE and MEDLINE to identify full-text English studies which aimed to develop or assess the measurement properties of radiographic outcome instruments in PsA. Determination of eligibility and data extraction was performed independently by two reviewers with input from a third to achieve consensus. Two reviewers assessed the methodology and results of eligible studies and synthesized the evidence using OMERACT methodology. Results: Twelve articles evaluating radiographic instruments were included. The articles assessed nine peripheral (hands, wrists and/or feet) and six axial (spinal and/or sacroiliac joints) radiographic instruments. The peripheral radiographic instruments with some evidence for reliability, cross-sectional construct validity and longitudinal construct validity were the Ratingen and modified Sharp van der Heijde scores. No instruments had evidence for clinical trial discrimination or thresholds of meaning. There was limited evidence for the measurement properties of all identified axial instruments. Conclusion: There are significant knowledge gaps in the responsiveness of peripheral radiographic instruments. Axial radiographic instruments require further validation, and the need to generate novel instruments and utilise other imaging modalities should be considered.

AB - Background: Structural damage is as an important outcome in the Psoriatic Arthritis (PsA) Core Domain Set and its assessment is recommended at least once in the development of a new drug. Objectives: To conduct a systematic review (SR) to identify studies addressing the measurement properties of radiographic outcome instruments for structural damage in PsA and appraise the evidence through the Outcome Measures in Rheumatology (OMERACT) Filter 2.1 Framework Instrument Selection Algorithm (OFISA). Methods: A SR was conducted using search strategies in EMBASE and MEDLINE to identify full-text English studies which aimed to develop or assess the measurement properties of radiographic outcome instruments in PsA. Determination of eligibility and data extraction was performed independently by two reviewers with input from a third to achieve consensus. Two reviewers assessed the methodology and results of eligible studies and synthesized the evidence using OMERACT methodology. Results: Twelve articles evaluating radiographic instruments were included. The articles assessed nine peripheral (hands, wrists and/or feet) and six axial (spinal and/or sacroiliac joints) radiographic instruments. The peripheral radiographic instruments with some evidence for reliability, cross-sectional construct validity and longitudinal construct validity were the Ratingen and modified Sharp van der Heijde scores. No instruments had evidence for clinical trial discrimination or thresholds of meaning. There was limited evidence for the measurement properties of all identified axial instruments. Conclusion: There are significant knowledge gaps in the responsiveness of peripheral radiographic instruments. Axial radiographic instruments require further validation, and the need to generate novel instruments and utilise other imaging modalities should be considered.

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KW - Outcome instruments

KW - Psoriatic Arthritis

KW - Radiography

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JO - Seminars in Arthritis and Rheumatism

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Measurement properties of radiographic outcome measures in Psoriatic Arthritis: A systematic review from the GRAPPA-OMERACT initiative

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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