Measurement of free light chains with assays based on monoclonal antibodies

Henk Te Velthuis, Mark Drayson, John P Campbell

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Recently, serum free light chain (FLC) assays incorporating anti-kappa (κ) and anti-lambda (λ) FLC monoclonal antibodies have become available: N Latex FLC assay (Siemens) and Seralite® (Abingdon Health). The purpose of this review is to provide an overview of these two new monoclonal antibody-based methods. In doing so, the review will outline the performance characteristics of each method, including a summary of: assay principles, antibody specificity, analytical performance and assay performance in disease. Additionally, the review will describe the potential user benefits of adopting these new generation FLC assays, which are designed to overcome the established limitations of existing polyclonal antibody based FLC assays.

Original languageEnglish
Pages (from-to)1005-1014
Number of pages10
JournalClinical Chemistry and Laboratory Medicine
Volume54
Issue number6
DOIs
Publication statusPublished - 1 Jun 2016

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