TY - JOUR
T1 - Maternal caffeine consumption during pregnancy and offspring cord blood DNA methylation
T2 - An epigenome-wide association study meta-analysis
AU - Schellhas, Laura
AU - Monasso, Giulietta S.
AU - Felix, Janine F.
AU - Jaddoe, Vincent W.V.
AU - Huang, Peiyuan
AU - Fernández-Barrés, Sílvia
AU - Vrijheid, Martine
AU - Pesce, Giancarlo
AU - Annesi-Maesano, Isabella
AU - Page, Christian M.
AU - Brantsæter, Anne Lise
AU - Bekkhus, Mona
AU - Håberg, Siri E.
AU - London, Stephanie J.
AU - Munafò, Marcus R.
AU - Zuccolo, Luisa
AU - Sharp, Gemma C.
PY - 2023/11/29
Y1 - 2023/11/29
N2 - Background: Prenatal caffeine exposure may influence offspring health via DNA methylation, but no large studies have tested this. Materials & methods: Epigenome-wide association studies and differentially methylated regions in cord blood (450k or EPIC Illumina arrays) were meta-analyzed across six European cohorts (n = 3725). Differential methylation related to self-reported caffeine intake (mg/day) from coffee, tea and cola was compared with assess whether caffeine is driving effects. Results: One CpG site (cg19370043, PRRX1) was associated with caffeine and another (cg14591243, STAG1) with cola intake. A total of 12-22 differentially methylated regions were detected with limited overlap across caffeinated beverages. Conclusion: We found little evidence to support an intrauterine effect of caffeine on offspring DNA methylation. Statistical power limitations may have impacted our findings.
AB - Background: Prenatal caffeine exposure may influence offspring health via DNA methylation, but no large studies have tested this. Materials & methods: Epigenome-wide association studies and differentially methylated regions in cord blood (450k or EPIC Illumina arrays) were meta-analyzed across six European cohorts (n = 3725). Differential methylation related to self-reported caffeine intake (mg/day) from coffee, tea and cola was compared with assess whether caffeine is driving effects. Results: One CpG site (cg19370043, PRRX1) was associated with caffeine and another (cg14591243, STAG1) with cola intake. A total of 12-22 differentially methylated regions were detected with limited overlap across caffeinated beverages. Conclusion: We found little evidence to support an intrauterine effect of caffeine on offspring DNA methylation. Statistical power limitations may have impacted our findings.
KW - caffeine
KW - DNA methylation
KW - epigenetics
KW - offspring health
KW - PACE consortium
KW - pregnancy
UR - http://www.scopus.com/inward/record.url?scp=85181263977&partnerID=8YFLogxK
U2 - 10.2217/epi-2023-0263
DO - 10.2217/epi-2023-0263
M3 - Review article
C2 - 38018434
AN - SCOPUS:85181263977
SN - 1750-1911
VL - 15
SP - 1179
EP - 1193
JO - Epigenomics
JF - Epigenomics
IS - 22
ER -
