MALDIViz: A Comprehensive Informatics Tool for MALDI-MS Data Visualization and Analysis

Kishore Kumar Jagadeesan, Simon Ekström

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Recently, mass spectrometry (MS) has emerged as an important tool for high-throughput screening (HTS) providing a direct and label-free detection method, complementing traditional fluorescent and colorimetric methodologies. Among the various MS techniques used for HTS, matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) provides many of the characteristics required for high-throughput analyses, such as low cost, speed, and automation. However, visualization and analysis of the large datasets generated by HTS MALDI-MS can pose significant challenges, especially for multiparametric experiments. The datasets can be generated fast, and the complexity of the experimental data (e.g., screening many different sorbent phases, the sorbent mass, and the load, wash, and elution conditions) makes manual data analysis difficult. To address these challenges, a comprehensive informatics tool called MALDIViz was developed. This tool is an R-Shiny-based web application, accessible independently of the operating system and without the need to install any program locally. It has been designed to facilitate easy analysis and visualization of MALDI-MS datasets, comparison of multiplex experiments, and export of the analysis results to high-quality images.
Original languageEnglish
Pages (from-to)1246-1252
Number of pages7
JournalSLAS DISCOVERY: Advancing Life Sciences R&D
Volume22
Issue number10
Early online date21 Aug 2017
DOIs
Publication statusPublished - 1 Dec 2017

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