Making digit patterns in the vertebrate limb

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Abstract

The vertebrate limb has been a premier model for studying pattern formation — a striking digit pattern is formed in human hands, with a thumb forming at one edge and a little finger at the other. Classic embryological studies in different model organisms combined with new sophisticated techniques that integrate gene-expression patterns and cell behaviour have begun to shed light on the mechanisms that control digit patterning, and stimulate re-evaluation of the current models.
Original languageEnglish
Pages (from-to)45-53
JournalNature Reviews Molecular Cell Biology
Volume7
DOIs
Publication statusPublished - Jan 2006

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